Viral kinetic (VK) modeling has led to increased understanding of the within host dynamics
of viral infections and the effects of therapy. Here we review recent developments in the …

Mathematically modelling changes in HCV RNA levels measured in patients who receive
antiviral therapy has yielded many insights into the pathogenesis and effects of treatment on …

About 170 million people worldwide are infected with hepatitis C virus (HCV). The current
standard therapy leads to sustained viral elimination in only~ 50% of the treated patients …

Nearly 200 million individuals worldwide are currently infected with hepatitis C virus (HCV).
Combination therapy with pegylated interferon and ribavirin, the latest treatment for HCV …

The current paradigm for studying hepatitis C virus (HCV) dynamics in patients utilizes a
standard viral dynamic model that keeps track of uninfected (target) cells, infected cells, and …

Viral kinetic modeling has played an important role in the analysis of HCV RNA decay after
the initiation of antiviral therapy. Models have provided a means of evaluating the antiviral …

Hepatitis C virus (HCV) infection remains a threat to global public health. Treatment with
pegylated interferon (IFN) plus ribavirin leads to a sustained virologic response in about …

By mathematically describing early hepatitis C virus (HCV) RNA decay after initiation of
interferon (IFN)‐based antiviral therapy, crucial parameters of the in vivo viral kinetics have …

Background & Aims: Kinetic modeling of hepatitis C virus (HCV) response to interferon (IFN)-
based therapy provides insights into factors associated with treatment outcomes …

Understanding the infection and pathogenesis mechanism of hepatitis B virus (HBV) is very
important for the prevention and treatment of hepatitis B. Mathematical models contribute to …