This article reviews technology trends in antibody purification. Section 1 discusses non-
chromatography methods, including precipitation, liquid–liquid extraction, and high …

For half a century aqueous two‐phase systems (ATPSs) have been applied for the extraction
and purification of biomolecules. In spite of their simplicity, selectivity, and relatively low cost …

The study shows significant process train simplification, uninterrupted and fully automated
purification to the DS over an extended period of time, steady state operation with respect to …

Plants offer the tantalizing prospect of low-cost automated manufacturing processes for
biopharmaceutical proteins, but several challenges must be addressed before such goals …

The downstream processing of virus particles for vaccination or gene therapy is becoming a
critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to …

Process development in the biotech industry leads to investments around hundred of
millions of dollars. It is important to mitigate costs without neglecting the quality of process …

Dramatic improvements in cell culture titers, product quality constraints, new regulatory
directives, and the emergence of biosimilars have necessitated the development of more …

Continuous production delivers higher productivity and better quality than traditional batch-
wise approaches. It intensifies production lowering capital cost and enables better control …

Bioprocess development today is slow and expensive compared to chemical process
development. A drastic paradigm shift is necessary and possible by the consistent …

Aqueous two‐phase systems (ATPS) have proved to be an efficient and integrative
operation to enhance recovery of industrially relevant bioproducts. After ATPS discovery, a …