Metabolic syndrome, which includes diabetes and obesity, is one of the most widespread
medical conditions. It induces systemic inflammation, causing far reaching effects on the …

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

The plasma membrane in eukaryotic cells contains microdomains that are enriched in
certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form …

Considerable progress has been made in understanding the basic mechanisms that
regulate fluid and protein exchange across the endothelial and epithelial barriers of the lung …

Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's
disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking …

J. Neurochem.(2012) 120, 147–156. Abstract The roles of caveolin‐1 (cav‐1) in regulating
blood–brain barrier (BBB) permeability are unclear yet. We previously reported that cav‐1 …

Rationale: Pulmonary arterial hypertension is a severe lethal cardiopulmonary disease.
Loss of function mutations in KCNK3 (potassium channel subfamily K member 3) gene …

The purpose of this review is to provide an overview of redox mechanisms, sources and
antioxidants that control signaling events in ECs. In particular, we describe which molecules …

Caveolae are an abundant feature of the plasma membrane of many mammalian cell types,
and have key roles in mechano-transduction, metabolic regulation, and vascular …