BACKGROUND: Nearly all processes in living cells are pH dependent, which is why
intracellular pH (pHi) is a tightly regulated physiological parameter in all cellular systems …

Positive-strand RNA viruses are the largest group of RNA viruses on Earth and cellular
membranes are critical for all aspects of their life cycle, from entry and replication to exit. In …

Recognition of lipids by proteins is important for their targeting and activation in many
signaling pathways, but the mechanisms that regulate such interactions are largely …

Luminal pH and the distinctive distribution of phosphatidylinositol phosphate (PIP) lipids are
central identifying features of organelles in all eukaryotic cells that are also critical for …

Posttranslational modification is an evolutionarily conserved mechanism for regulating
protein activity, binding affinity, and stability. Compared with established posttranslational …

Actin cytoskeleton dynamics depend on a tight regulation of actin filament formation from an
intracellular pool of monomers, followed by their linkage to each other or to cell membranes …

Septins are conserved cytoskeletal proteins that regulate cell cortex mechanics. The
mechanisms of their interactions with the plasma membrane remain poorly understood …

The lipid phosphatidic acid (PA) has important roles in cell signaling and metabolic
regulation in all organisms. New evidence indicates that PA also has an unprecedented role …

Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to
biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are …

Phosphoinositides are a family of membrane phospholipids that play crucial roles in
membrane regulatory events. As such, these lipids are often a key part of molecular …