Fluorine-containing drugs approved by the FDA in 2021
J He, Z Li, G Dhawan, W Zhang, AE Sorochinsky… - Chinese Chemical …, 2023 - Elsevier
Nine new fluorine-containing drugs have been approved by the US Food and Drug
Administration (FDA) in 2021, which are presented in this review article. These small …
Administration (FDA) in 2021, which are presented in this review article. These small …
Vascular actions of calcitonin gene-related peptide and adrenomedullin
SD Brain, AD Grant - Physiological reviews, 2004 - journals.physiology.org
This review summarizes the receptor-mediated vascular activities of calcitonin gene-related
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …
peptide (CGRP) and the structurally related peptide adrenomedullin (AM). CGRP is a 37 …
ARISE: a phase 3 randomized trial of erenumab for episodic migraine
DW Dodick, M Ashina, JL Brandes, D Kudrow… - …, 2018 - journals.sagepub.com
Background Calcitonin gene-related peptide plays an important role in migraine
pathophysiology. Erenumab, a human monoclonal antibody that inhibits the calcitonin gene …
pathophysiology. Erenumab, a human monoclonal antibody that inhibits the calcitonin gene …
Safety and efficacy of erenumab for preventive treatment of chronic migraine: a randomised, double-blind, placebo-controlled phase 2 trial
Background The calcitonin gene-related peptide (CGRP) pathway is important in migraine
pathophysiology. We assessed the efficacy and safety of erenumab, a fully human …
pathophysiology. We assessed the efficacy and safety of erenumab, a fully human …
Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine
E Cernuda-Morollón, D Larrosa, C Ramón, J Vega… - Neurology, 2013 - AAN Enterprises
Objective: To determine calcitonin gene-related peptide (CGRP) levels outside migraine
attacks in peripheral blood as a potential biomarker for chronic migraine (CM). Methods …
attacks in peripheral blood as a potential biomarker for chronic migraine (CM). Methods …
Tension-type headache
Tension-type headache (TTH) is the most prevalent neurological disorder worldwide and is
characterized by recurrent headaches of mild to moderate intensity, bilateral location …
characterized by recurrent headaches of mild to moderate intensity, bilateral location …
Neurobiology of migraine
PJ Goadsby, AR Charbit, AP Andreou, S Akerman… - Neuroscience, 2009 - Elsevier
Migraine is a complex disorder of the brain whose mechanisms are only now being
unraveled. It is common, disabling and economically costly. The pain suggests an important …
unraveled. It is common, disabling and economically costly. The pain suggests an important …
Tension-type headache: current research and clinical management
A Fumal, J Schoenen - The Lancet Neurology, 2008 - thelancet.com
Tension-type headache (TTH) is the most common form of headache, and chronic tension-
type headache (CTTH) is one of the most neglected and difficult types of headache to treat …
type headache (CTTH) is one of the most neglected and difficult types of headache to treat …
Calcitonin receptor‐like receptor (CLR), receptor activity‐modifying protein 1 (RAMP1), and calcitonin gene‐related peptide (CGRP) immunoreactivity in the rat …
Calcitonin gene‐related peptide (CGRP) is a key mediator in primary headaches including
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …
OnabotulinumtoxinA decreases interictal CGRP plasma levels in patients with chronic migraine
E Cernuda-Morollón, C Ramón, P Martínez-Camblor… - Pain, 2015 - journals.lww.com
OnabotulinumtoxinA (onabotA) has shown efficacy in chronic migraine (CM). Its mechanism
of action, however, remains obscure. We have analysed whether treatment with onabotA is …
of action, however, remains obscure. We have analysed whether treatment with onabotA is …