Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Abstract Here, in Ppara−/− mice, we found that an increased DNL stimulated the cartilage
degradation and identified ACOT12 as a key regulatory factor. Suppressed level of ACOT12 …

Obesity and associated metabolic diseases collectively referred to as the metabolic
syndrome increase the risk of skeletal and synovial joint diseases, including osteoarthritis …

The gut microbiome impacts bone mass, which implies a disruption to bone homeostasis.
However, it is not yet clear how the gut microbiome affects the regulation of bone mass and …

Chondrocytes are the sole cell type found in articular cartilage and are repeatedly subjected
to mechanical loading in vivo. We hypothesized that physiological dynamic compression …

Osteoarthritis is the most common chronic joint disease, characterized by the abnormal
remodeling of joint tissues including articular cartilage and subchondral bone. However …

Chondrocytes use the pathways of central metabolism to synthesize molecular building
blocks and energy for cartilage homeostasis. An interesting feature of the in vivo …

In articular cartilage, chondrocytes reside within a gel-like pericellular matrix (PCM). This
matrix provides a mechanical link through which joint loads are transmitted to chondrocytes …

Objective Although joint injury itself damages joint tissues, a substantial amount of
secondary damage is mediated by the cellular responses to the injury. Cellular responses …