YB‐1 protein: functions and regulation

DN Lyabin, IA Eliseeva… - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …

Y-box-binding protein 1 (YB-1) and its functions

IA Eliseeva, ER Kim, SG Guryanov… - Biochemistry …, 2011 - Springer
This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

Multiomics analyses reveal DARS1-AS1/YBX1–controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance

C Zheng, Y Wei, Q Zhang, M Sun, Y Wang, J Hou… - Science …, 2023 - science.org
The glioblastoma (GBM) stem cell–like cells (GSCs) are critical for tumorigenesis/therapeutic
resistance of GBM. Mounting evidence supports tumor-promoting function of long noncoding …

The pleiotropic functions of the Y‐box‐binding protein, YB‐1

K Kohno, H Izumi, T Uchiumi, M Ashizuka… - …, 2003 - Wiley Online Library
The Y‐box‐binding protein (YB‐1) represents the most evolutionary conserved nucleic‐acid‐
binding protein currently known. YB‐1 is a member of the cold‐shock domain (CSD) protein …

[HTML][HTML] Reducing hypothalamic stem cell senescence protects against aging-associated physiological decline

YZ Xiao, M Yang, Y Xiao, Q Guo, Y Huang, CJ Li, D Cai… - Cell metabolism, 2020 - cell.com
Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for the
pathological consequences of aging; however, it is unclear what drives the senescence of …

A comprehensive review of the functions of YB-1 in cancer stemness, metastasis and drug resistance

A Alkrekshi, W Wang, PS Rana, V Markovic… - Cellular signalling, 2021 - Elsevier
The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …

[HTML][HTML] Y-box binding proteins in mRNP assembly, translation, and stability control

D Mordovkina, DN Lyabin, EA Smolin, EM Sogorina… - Biomolecules, 2020 - mdpi.com
Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large
family of proteins with the cold shock domain. Functionally, these proteins are known to be …

[HTML][HTML] The major mRNA‐associated protein YB‐1 is a potent 5′ cap‐dependent mRNA stabilizer

V Evdokimova, P Ruzanov, H Imataka, B Raught… - The EMBO …, 2001 - embopress.org
mRNA silencing and storage play an important role in gene expression under diverse
circumstances, such as throughout early metazoan development and in response to many …

Bacterial cold-shock proteins

DN Ermolenko, GI Makhatadze - Cellular and Molecular Life Sciences …, 2002 - Springer
Members of a family of small cold-shock proteins (CSPs) are induced during bacterial cell
response to a temperature decrease. Here we review available data about the structure …

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

NC de Souza-Pinto, PA Mason, K Hashiguchi… - DNA repair, 2009 - Elsevier
Maintenance of the mitochondrial genome (mtDNA) is essential for proper cellular function.
The accumulation of damage and mutations in the mtDNA leads to diseases, cancer, and …