The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …

Whole cell biosensors (WCBs) have multiple applications for environmental monitoring,
detecting a wide range of pollutants. WCBs depend critically on the sensitivity and specificity …

Bacterial populations co-ordinate gene expression collectively through quorum sensing
(QS), a cell-to-cell communication mechanism employing diffusible signal molecules. The …

The coordination of carbon and nitrogen metabolism is essential for bacteria to adapt to
nutritional variations in the environment, but the underlying mechanism remains poorly …

LysR-type transcriptional regulators (LTTRs) form one of the largest families of bacterial
regulators. They are widely distributed and contribute to all aspects of metabolism and …

Bacterial antibiotic resistance is a worldwide health problem that deserves important
research attention in order to develop new therapeutic strategies. Recently, the World Health …

Novel biophysical tools allow the structural dynamics of proteins and the regulation of such
dynamics by binding partners to be explored in unprecedented detail. Although this has …

The LysR-type transcriptional regulators (LTTRs) are DNA-binding proteins present in
bacteria, archaea, and in algae. Knowledge about their distribution, abundance, evolution …

Inducible expression of chromosomal AmpC β-lactamase is a major cause of β-lactam
antibiotic resistance in the Gram-negative bacteria Pseudomonas aeruginosa and …

Structure predictions have matched the accuracy of experimental structures from close
homologues, providing suitable models for molecular replacement phasing. Even in …