Polypharmacology: drug discovery for the future
AS Reddy, S Zhang - Expert review of clinical pharmacology, 2013 - Taylor & Francis
In recent years, even with remarkable scientific advancements and a significant increase of
global research and development spending, drugs are frequently withdrawn from markets …
global research and development spending, drugs are frequently withdrawn from markets …
[HTML][HTML] Environmental arsenic exposure: from genetic susceptibility to pathogenesis
More than 200 million people in 70 countries are exposed to arsenic through drinking water.
Chronic exposure to this metalloid has been associated with the onset of many diseases …
Chronic exposure to this metalloid has been associated with the onset of many diseases …
The comparative toxicogenomics database: update 2019
AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is a premier
public resource for literature-based, manually curated associations between chemicals …
public resource for literature-based, manually curated associations between chemicals …
The comparative toxicogenomics database: update 2017
AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2017 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) provides
information about interactions between chemicals and gene products, and their …
information about interactions between chemicals and gene products, and their …
CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental …
AP Davis, TC Wiegers, J Wiegers, B Wyatt… - Toxicological …, 2023 - academic.oup.com
The molecular mechanisms connecting environmental exposures to adverse endpoints are
often unknown, reflecting knowledge gaps. At the Comparative Toxicogenomics Database …
often unknown, reflecting knowledge gaps. At the Comparative Toxicogenomics Database …
The Comparative Toxicogenomics Database's 10th year anniversary: update 2015
AP Davis, CJ Grondin, K Lennon-Hopkins… - Nucleic acids …, 2015 - academic.oup.com
Ten years ago, the Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) was
developed out of a need to formalize, harmonize and centralize the information on …
developed out of a need to formalize, harmonize and centralize the information on …
The comparative toxicogenomics database: update 2013
AP Davis, CG Murphy, R Johnson, JM Lay… - Nucleic acids …, 2013 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) provides
information about interactions between environmental chemicals and gene products and …
information about interactions between environmental chemicals and gene products and …
Linking human diseases to animal models using ontology-based phenotype annotation
Scientists and clinicians who study genetic alterations and disease have traditionally
described phenotypes in natural language. The considerable variation in these free-text …
described phenotypes in natural language. The considerable variation in these free-text …
Zebrafish as a systems toxicology model for developmental neurotoxicity testing
Y Nishimura, S Murakami, Y Ashikawa… - Congenital …, 2015 - Wiley Online Library
The developing brain is extremely sensitive to many chemicals. Exposure to neurotoxicants
during development has been implicated in various neuropsychiatric and neurological …
during development has been implicated in various neuropsychiatric and neurological …
The comparative toxicogenomics database: update 2011
Abstract The Comparative Toxicogenomics Database (CTD) is a public resource that
promotes understanding about the interaction of environmental chemicals with gene …
promotes understanding about the interaction of environmental chemicals with gene …