Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

Cytoplasmic dynein-1 binds dynactin and cargo adaptor proteins to form a transport
machine capable of long-distance processive movement along microtubules. However, it is …

Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1. We report
the structure of the 23-subunit dynactin complex by cryo-electron microscopy to 4.0 …

Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …

Life depends on cell proliferation and the accurate segregation of chromosomes, which are
mediated by the microtubule (MT)-based mitotic spindle and∼ 200 essential MT-associated …

Until recently, dynein was the least understood of the cytoskeletal motors. However, a wealth
of new structural, mechanistic, and cell biological data is shedding light on how this …

Motor-cargo recruitment to microtubules is often the rate-limiting step of intracellular
transport, and defects in this recruitment can cause neurodegenerative disease. Here, we …

Post‐translational modifications (PTM s) of α/β‐tubulin are believed to regulate interactions
with microtubule‐binding proteins. A well‐characterized PTM involves in the removal and re …

Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …