Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid derived from Cannabis
sativa. It has possible therapeutic effects over a broad range of neuropsychiatric disorders …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Depression, a severe psychiatric disorder, has been studied for decades, but the underlying
mechanisms still remain largely unknown. Depression is closely associated with alterations …

Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …

Major depressive disorder (MDD) is one of the most common psychiatric disorder, but the
underlying mechanisms are largely unknown. Increasing evidence shows that brain-derived …

Background Chronic restraint stress (CRS) is widely used to recapitulate depression
phenotypes in rodents but is frequently criticized for a perceived lack of efficacy. The aim of …

Disrupted serotonergic neurotransmission has long been implicated in major depressive
disorder (MDD), for which selective serotonin reuptake inhibitors (SSRIs) are the first line of …

Depression, a mood disorder, affects one in fifteen adults, has multiple risk factors and is
associated with complicated underlying pathological mechanisms. P-coumaric acid (p-CA) …

The organization of the brain serotonergic system appears to have been highly conserved
across the vertebrate subphylum. In fish as well as in other vertebrates, brain serotonin (5 …

Suicide is a major public health concern. A significant proportion of depressed individuals
show suicidal ideation. The currently available medications are not optimal and a large …