The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

In obesity and dyslipidemia, the oversupply of fat to tissues not suited for lipid storage
induces cellular dysfunction that underlies diabetes and cardiovascular disease (ie …

Objective—Ceramides are sphingolipids involved with cellular signaling. Synthesis of
ceramides occurs in all tissues. Ceramides accumulate within tissues and the blood plasma …

Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD) and
atherosclerotic cardiovascular disease (ASCVD). These diseases share common …

Ceramide is a core molecule of sphingolipid metabolism that causes selective insulin
resistance and dyslipidemia. Research on its involvement in cardiovascular diseases has …

Cardiovascular diseases (CVDs) are the leading cause of death and illness in Europe and
worldwide, responsible for a staggering 47% of deaths in Europe. Over the past few years …

There is a need for new biomarkers of atherosclerotic cardiovascular disease (ACVD), the
main cause of death globally. Ceramides, a class of potent bioactive lipid mediators, have …

Sphingolipids are bioactive molecules that play either pro-and anti-atherogenic roles in the
formation and maturation of atherosclerotic plaques. Among SLs, ceramide and sphingosine …

Diabetic nephropathy (DN) is one of the serious complications of diabetes mellitus, primarily
arising from type 2 diabetes (T2DM), and can progress to chronic kidney disease (CKD) and …