Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% of all
mortalities worldwide. Transient or permanent occlusion of cerebral vessels leads to …

Background and Purpose—The purpose of these guidelines is to provide an up-to-date
comprehensive set of recommendations in a single document for clinicians caring for adult …

Background Trials of the efficacy and safety of endovascular thrombectomy in patients with
large ischemic strokes have been carried out in limited populations. Methods We performed …

Background The effects and risks of endovascular thrombectomy 6 to 24 hours after stroke
onset due to basilar-artery occlusion have not been extensively studied. Methods In a trial …

Background Data from trials investigating the effects and risks of endovascular
thrombectomy for the treatment of stroke due to basilar-artery occlusion are limited. Methods …

Background Endovascular therapy for acute ischemic stroke is generally avoided when the
infarction is large, but the effect of endovascular therapy with medical care as compared with …

Background There is increasing interest in replacing alteplase with tenecteplase as the
preferred thrombolytic treatment for patients with acute ischaemic stroke. We aimed to …

Importance Whether intravenous thrombolysis is needed in combination with mechanical
thrombectomy in patients with acute large vessel occlusion stroke is unclear. Objective To …

Ischemic stroke (IS) is one of the most common causes of disability and death. Thrombolysis
and neuroprotection are two current major therapeutic strategies to overcome ischemic and …

Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …