The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans

BAH Smith, CR Bertozzi - Nature reviews Drug discovery, 2021 - nature.com
Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Targeting strategies for tissue-specific drug delivery

Z Zhao, A Ukidve, J Kim, S Mitragotri - Cell, 2020 - cell.com
Off-target effects of systemically administered drugs have been a major hurdle in designing
therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to …

Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Mesenchymal stromal cell homing: mechanisms and strategies for improvement

M Ullah, DD Liu, AS Thakor - Iscience, 2019 - cell.com
Mesenchymal stromal cells (MSCs) have been widely investigated for their therapeutic
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …

Leukaemia: a model metastatic disease

AE Whiteley, TT Price, G Cantelli, DA Sipkins - Nature Reviews Cancer, 2021 - nature.com
In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Biomimetic cell membrane‐coated poly(lactic‐co‐glycolic acid) nanoparticles for biomedical applications

N Jan, A Madni, S Khan, H Shah… - Bioengineering & …, 2023 - Wiley Online Library
Poly (lactic‐co‐glycolic acid)(PLGA) nanoparticles (NPs) are commonly used for drug
delivery because of their favored biocompatibility and suitability for sustained and controlled …

Cell membrane-derived nanomaterials for biomedical applications

RH Fang, Y Jiang, JC Fang, L Zhang - Biomaterials, 2017 - Elsevier
The continued evolution of biomedical nanotechnology has enabled clinicians to better
detect, prevent, manage, and treat human disease. In order to further push the limits of …