Biomedical applications, perspectives and tag design concepts in the cell-silent Raman window

M Vardaki, VG Gregoriou, CL Chochos - RSC Chemical Biology, 2024 - pubs.rsc.org
Spectroscopic studies increasingly employ Raman tags exhibiting a signal in the cell-silent
region of the Raman spectrum (1800-2800 cm-1), where bands arising from biological …

Measuring Drug Response with Single-Cell Growth Rate Quantification

FX Xu, R Wu, K Hu, D Fu - Analytical Chemistry, 2023 - ACS Publications
Intratumoral heterogeneity is a substantial cause of drug resistance development during
chemotherapy or other drug treatments for cancer. Therefore, monitoring and measuring cell …

Video-rate Raman-based metabolic imaging by Airy light-sheet illumination and photon-sparse detection

L Dunn, H Luo, NR Subedi, R Kasu… - Proceedings of the …, 2023 - National Acad Sciences
Despite its massive potential, Raman imaging represents just a modest fraction of all
research and clinical microscopy to date. This is due to the ultralow Raman scattering cross …

Imaging the uptake of deuterated methionine in Drosophila with stimulated Raman scattering

SJ Spratt, T Mizuguchi, H Akaboshi… - Frontiers in …, 2023 - frontiersin.org
Introduction: Visualizing small individual biomolecules at subcellular resolution in live cells
and tissues can provide valuable insights into metabolic activity in heterogeneous cells, but …

Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q

S Moriyama, M Mae, D Shibata, H Yamakoshi… - Chemical …, 2023 - pubs.rsc.org
All aromatic C–H bonds of triphenylphosphine (PPh3) were efficiently replaced by C–D
bonds using Ru/C and Ir/C co-catalysts in 2-PrOH and D2O, an inexpensive deuterium …

Visualization of Modified Bisarylbutadiyne-Tagged Small Molecules in Live-Cell Nuclei by Stimulated Raman Scattering Microscopy

M Kawaguchi, Y Yonetani, T Mizuguchi… - Analytical …, 2024 - ACS Publications
Visualizing the distribution of small-molecule drugs in living cells is an important strategy for
developing specific, effective, and minimally toxic drugs. As an alternative to fluorescence …

Unprecedented Regioselective Deuterium‐Incorporation of Alkyltrimethylammonium Chlorides and Raman Analysis

Y Sawama, T Matsuda, S Moriyama… - Asian Journal of …, 2023 - Wiley Online Library
Alkyltrimethylammonium chlorides (ATACs) are widely utilized as cationic surfactants in
various scientific fields. Furthermore, deuterium‐incorporated compounds can be powerful …

Widely tunable fiber optical parametric oscillator synchronized with a Ti: sapphire laser for stimulated Raman scattering microscopy

S Takahashi, K Oguchi, K Kamei… - Biomedical Optics …, 2024 - opg.optica.org
Stimulated Raman scattering (SRS) microscopy is a powerful vibrational imaging technique
with high chemical specificity. However, the insufficient tuning range or speed of light …

All-fiber polarization-maintaining system for noise suppression and signal amplification of picosecond pulses

G Dai, Y Ozeki - Japanese Journal of Applied Physics, 2022 - iopscience.iop.org
We present an all–fiber polarization-maintaining system, which consists of an ultralow-
intensity-noise picosecond Yb mode-locked fiber oscillator, a Yb-doped fiber amplifier and a …

Homemade Solution of NaOD in D2O: Applications in the Field of Stilbene‐d1 Synthesis

K Imai, N Tomita, H Fujioka, M Kamiya… - Asian Journal of …, 2023 - Wiley Online Library
The development of deuterium‐incorporation method is eagerly desired. A solution of
sodium deuteroxide in deuterium oxide (NaOD in D2O) was simply prepared by mixing D2O …