Design and testing of a humanized porcine donor for xenotransplantation

RP Anand, JV Layer, D Heja, T Hirose, G Lassiter… - Nature, 2023 - nature.com
Recent human decedent model studies, and compassionate xenograft use have explored
the promise of porcine organs for human transplantation. To proceed to human studies, a …

[HTML][HTML] ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs

H Yang, J Wu, X Huang, Y Zhou, Y Zhang, M Liu, Q Liu… - Nature, 2022 - nature.com
The composition of the intestinal microbiome varies considerably between individuals and is
correlated with health. Understanding the extent to which, and how, host genetics …

Employing pigs to decipher the host genetic effect on gut microbiome: advantages, challenges, and perspectives

L Huang, C Chen - Gut Microbes, 2023 - Taylor & Francis
The gut microbiota is a complex and diverse ecosystem comprised of trillions of microbes
and plays an essential role in host's immunity, metabolism, and even behaviors …

Investigation of ABO Gene Variants across More Than 60 Pig Breeds and Populations and Other Suidae Species Using Whole-Genome Sequencing Datasets

M Bolner, F Bertolini, S Bovo, G Schiavo, L Fontanesi - Animals, 2023 - mdpi.com
Simple Summary The ABO gene is the major blood classification system, which, in humans,
is present in three main forms: A; B; and O. Under the umbrella of these main forms, other …

Prevalence of AO blood group and level of agreement for AO blood‐typing methods in pet pigs from Louisiana

C Hampton, S Dehghanpir, C Armstrong… - Journal of Veterinary …, 2023 - Wiley Online Library
Objectives Pet pigs are a species of growing medical interest, and evidence‐based
practices for blood transfusions are needed. The objectives of this study were to quantify the …

Genetic diversity, growth and heart function of Auckland Island pigs, a potential source for organ xenotransplantation

A Lange, I Medugorac, A Ali, B Kessler… - …, 2024 - Wiley Online Library
One of the prerequisites for successful organ xenotransplantation is a reasonable size
match between the porcine organ and the recipient's organ to be replaced. Therefore, the …

Recipients with blood group A associated with longer survival rates in cardiac valvular bioprostheses

O Schussler, N Lila, T Perneger, P Mootoosamy… - …, 2019 - thelancet.com
Background Pigs/bovines share with humans some of the antigens present on cardiac
valves. Two such antigens are: the major xenogenic Ag," Gal" present in all pig/bovine very …

Possible link between the ABO Blood Group of bioprosthesis recipients and specific types of structural degeneration

O Schussler, N Lila, J Grau, M Ruel… - Journal of the …, 2020 - Am Heart Assoc
Background Pigs/bovines share common antigens with humans: α‐Gal, present in all
pigs/bovines close to the human B‐antigen; and AH‐histo‐blood‐group antigen, identical to …

猪血型PCR 鉴定方法的建立

王娇祥, 王艳, 胡珂, 徐凯祥, 魏太云, 角德灵… - 实验动物与比较 …, 2023 - slarc.org.cn
目的异种器官移植是解决人类器官供体短缺的有效途径, 但其面临严重的免疫排斥反应,
包括血型差异导致的超急性排斥反应. 建立稳定, 便捷, 可靠的猪血型鉴定方法 …

An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations

H Yang, J Wu, X Huang, Y Zhou, Y Zhang, M Liu, Q Liu… - bioRxiv, 2020 - biorxiv.org
We have generated a large heterogenous stock population by intercrossing eight divergent
pig breeds for multiple generations. We have analyzed the composition of the intestinal …