Induced pluripotent stem cells (iPSCs) are reprogrammed cells that have features similar to
embryonic stem cells, such as the capacity of self-renewal and differentiation into many …

The heart is a major target organ for thyroid hormone action, and marked changes occur in
cardiac function in patients with hypo-or hyperthyroidism. T3-induced changes in cardiac …

Contractile and energetic properties of human skeletal muscle have been studied for many
years in vivo in the body. It has been, however, difficult to identify the specific role of muscle …

Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …

In the heart, the relative proportions of the 2 forms of the motor protein myosin heavy chain
(MyHC) have been shown to be affected by a wide variety of pathological and physiological …

Cardiomyocytes from human pluripotent stem cells (hPSC-CM) have many potential
applications in disease modelling and drug target discovery but their phenotypic similarity to …

Using quantitative RT-PCR in RNA from right ventricular (RV) endomyocardial biopsies from
intact nonfailing hearts, and subjects with moderate RV failure from primary pulmonary …

Two isoforms of myosin heavy chain (MyHC), alpha and beta, exist in the mammalian
ventricular myocardium, and their relative expression is correlated with the contractile …

Expression of the cardiac myosin isozymes is regulated during development, by hormonal
stimuli and hemodynamic load. In this study, the levels of expression of the two isoforms …

Hypertrophic cardiomyopathy is characterized by left and/or right ventricular hypertrophy,
which is usually asymmetric and involves the interventricular septum. Typical morphological …