Proteolysis targeting chimera (PROTAC) presents a powerful strategy for targeted protein
degradation (TPD). The heterobifunctional PROTAC molecule consists of an E3 ligase …

The WD40 repeat (WDR) domain is one of the most abundant protein interaction domains in
the human proteome. More than 360 protein interaction domains have been annotated thus …

Sugar beet is one of the most important sugar crops in the world. It contributes greatly to the
global sugar production, but salt stress negatively affects the crop yield. WD40 proteins play …

Sperm motility, the percentage of sperm with forward progressions, is one of the semen
quality traits that is highly related with male fertility potential in farm animals. The proportion …

Neuromuscular disorders encompass a broad range of phenotypes and genetic causes. We
investigated a consanguineous family in which multiple patients had a neuromuscular …

Cullin-RING finger ligases represent the largest family of ubiquitin ligases. They are
responsible for the ubiquitination of∼ 20% of cellular proteins degraded through the …

Spermatogenesis is a complex process that includes spermatogonia self-renewal,
spermatocyte meiosis and spermatozoa assembly. Recent studies have revealed that WD40 …

The mouse WD repeat and FYVE domain containing 1 (Wdfy1) gene is located in
chromosome 1qC4 and spans over 73.7 kilobases. It encodes a protein of 410-amino acid …

Male infertility is a common condition affecting at least 7% of men worldwide and is often
genetic in origin. Using whole exome sequencing, we recently discovered three …

The WD40-repeat containing (WDR) proteins are enriched in the testis and play important
roles in spermatogenesis. In the present study, we investigate the expression profile of …