Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

Mitochondria are key cell organelles in that they are responsible for energy production and
control many processes from signalling to cell death. The function of the mitochondrial …

Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …

Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Protein aggregation causes α-synuclein to switch from its physiological role to a pathological
toxic gain of function. Under physiological conditions, monomeric α-synuclein improves ATP …

Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic
Parkinson's disease (PD). However, strategies aimed at ameliorating mitochondrial …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Neurodegenerative disorders are currently incurable devastating diseases which are
characterized by the slow and progressive loss of neurons in specific brain regions …

Abstract α-Synuclein is strongly linked to Parkinson's disease but the molecular targets for its
toxicity are not fully clear. However, many neuronal functions damaged in Parkinson's …