miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

Macrophages have protective roles in immunity to pathogens, tissue development,
homeostasis and repair following damage. Maladaptive immunity and inflammation provoke …

MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how
miRNA circuits orchestrate aberrant intestinal inflammation during inflammatory bowel …

The prevalence of overweight and obesity in developed and developing countries has
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …

The non-canonical NF-κB pathway is an important arm of NF-κB signaling that
predominantly targets activation of the p52/RelB NF-κB complex. This pathway depends on …

Cognitive dysfunctions such as mild cognitive impairment (MCI), Alzheimer's disease (AD),
and other forms of dementia are recognized as common comorbidities of type 2 diabetes …

The noncanonical nuclear factor‐κB (NF‐κB) signaling pathway mediates activation of the
p52/RelB NF‐κB complex and, thereby, regulates specific immunological processes. This …

The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …

Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation
and to allow for tissue repair and the return to homeostasis after infection and tissue injury …