The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …

Urine is a valuable diagnostic medium and, with the discovery of urinary extracellular
vesicles, is viewed as a dynamic bioactive fluid. Extracellular vesicles are lipid-enclosed …

Tubulointerstitial abnormalities are predictive of the progression of diabetic kidney disease
(DKD), and their targeting may be an effective means for prevention. Proximal tubular (PT) …

Abstract Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important
potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute …

Apoptosis and the clearance of apoptotic cells are essential processes in animal
development and homeostasis. For apoptotic cells to be cleared, they must display an 'eat …

Since the pioneering work of Elie Metchnikoff and the discovery of cellular immunity, the
phagocytic clearance of cellular debris has been considered an integral component of …

Acute kidney injury is an increasingly common complication of hospital admission and is
associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult …

There is an alarming global increase in the incidence of end-stage kidney disease, for which
early biomarkers and effective treatment options are lacking. Largely based on the histology …

Various biomarkers of acute kidney injury (AKI) have been discovered and characterized in
the recent past. These molecules can be detected in urine or blood and signify structural …

Phagocytosis is a remarkably complex and versatile process: it contributes to innate
immunity through the ingestion and elimination of pathogens, while also being central to …