Dendritic cells (DCs) can be viewed as translators between innate and adaptive immunity.
They integrate signals derived from tissue infection or damage and present processed …

The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability,
as seen with other human coronavirus epidemics. To address the underlying etiology, we …

Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …

Humoral immunity depends on the germinal centre (GC) reaction during which somatically
mutated high-affinity memory B cells and plasma cells are generated. Recent studies have …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

There is little insight into or agreement about the signals that control differentiation of
memory B cells (MBCs) and long-lived plasma cells (LLPCs). By performing BrdU pulse …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

B cells can present antigens to CD4+ T cells, but it is thought that dendritic cells (DCs) are
the primary initiators of naive CD4+ T cell responses. Nanoparticles, including virus-like …

Cell fate decisions during early B cell activation determine the outcome of responses to
pathogens and vaccines. We examined the early B cell response to T-dependent antigen in …