The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

CB2 was first considered to be the 'peripheral cannabinoid receptor'. This title was bestowed
based on its abundant expression in the immune system and presumed absence from the …

Background and Purpose Paclitaxel (PAC) is associated with chemotherapy‐induced
neuropathic pain (CIPN) that can lead to the cessation of treatment in cancer patients even …

An overview of the cannabinoid type 2 receptor system and it... : Current Opinion in
Anesthesiology An overview of the cannabinoid type 2 receptor system and its therapeutic …

Neuropathic pain is a debilitating form of chronic pain resulting from nerve injury, disease
states, or toxic insults. Neuropathic pain is often refractory to conventional …

Glial activation participates in the mediation of pain including neuropathic pain, due to
release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

A ruthenium (II)‐catalyzed asymmetric intramolecular hydroarylation assisted by a chiral
transient directing group has been developed. A series of 2, 3‐dihydrobenzofurans bearing …

Background Mixed cannabinoid receptor 1 and 2 (CB 1 and CB 2) agonists such as Δ 9-
tetrahydrocannabinol (Δ 9-THC) can produce tolerance, physical withdrawal, and unwanted …

The management of visceral pain in patients with disorders of gut–brain interaction, notably
irritable bowel syndrome, presents a considerable clinical challenge, with few available …