Update on NAFLD genetics: from new variants to the clinic
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …
the emerging role of genetics in precision medicine for patients with non‐alcoholic steatohepatitis
B Carlsson, D Lindén, G Brolén… - Alimentary …, 2020 - Wiley Online Library
Background Non‐alcoholic steatohepatitis (NASH) is a severe form of non‐alcoholic fatty
liver disease (NAFLD) characterised by liver fat accumulation, inflammation and progressive …
liver disease (NAFLD) characterised by liver fat accumulation, inflammation and progressive …
Genome-wide analysis of somatic noncoding mutation patterns in cancer
We established a genome-wide compendium of somatic mutation events in 3949 whole
cancer genomes representing 19 tumor types. Protein-coding events captured well …
cancer genomes representing 19 tumor types. Protein-coding events captured well …
[HTML][HTML] KASL clinical practice guidelines: management of nonalcoholic fatty liver disease
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing rapidly worldwide
as the obese and diabetic populations increase, and it has been estimated to be 20–30% in …
as the obese and diabetic populations increase, and it has been estimated to be 20–30% in …
[HTML][HTML] Diagnosis and management of secondary causes of steatohepatitis
R Liebe, I Esposito, HH Bock, S Vom Dahl, J Stindt… - Journal of …, 2021 - Elsevier
The term non-alcoholic liver disease (NAFLD) was originally coined to describe hepatic fat
deposition as part of the metabolic syndrome. However, a variety of rare hereditary liver and …
deposition as part of the metabolic syndrome. However, a variety of rare hereditary liver and …
[PDF][PDF] Genetic pathways in nonalcoholic fatty liver disease: insights from systems biology
Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning worldwide epidemic
whose etiology reflects multiple interactions between environmental and genetic factors …
whose etiology reflects multiple interactions between environmental and genetic factors …
Emerging role of genomic analysis in clinical evaluation of lean individuals with NAFLD
Results We found that ALCDs are critical regions of the human genome that are located on
all human chromosomes, preferentially in intronic regions of the oncogenes and other …
all human chromosomes, preferentially in intronic regions of the oncogenes and other …
Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4
Z Zhu, Y Zhang, X Huang, L Can, X Zhao… - European Journal of …, 2021 - Elsevier
Abstract Thymosin beta 4 (Tβ4) can improve the liver fibrosis and reduce inflammation, while
the role of Tβ4 in non-alcoholic fatty liver disease (NAFLD) whether mediated by ferroptosis …
the role of Tβ4 in non-alcoholic fatty liver disease (NAFLD) whether mediated by ferroptosis …
Toward genetic prediction of nonalcoholic fatty liver disease trajectories: PNPLA3 and beyond
M Krawczyk, R Liebe, F Lammert - Gastroenterology, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is on the verge of becoming the leading cause of
liver disease. NAFLD develops at the interface between environmental factors and inherited …
liver disease. NAFLD develops at the interface between environmental factors and inherited …
[HTML][HTML] Research techniques made simple: whole-transcriptome sequencing by RNA-seq for diagnosis of monogenic disorders
Mendelian disorders with cutaneous manifestations comprise a genotypically
heterogeneous group of over 1,000 diseases, and in most of them mutant genes have been …
heterogeneous group of over 1,000 diseases, and in most of them mutant genes have been …