Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …

Benzimidazole is a heterocyclic ring system that has been widely studied in the
pharmaceutical field. For the past decade, numerous benzimidazole derivatives have been …

Intrauterine growth restriction (IUGR) is a serious pathological complication associated with
compromised fetal development during pregnancy. The aim of the study was to broaden …

Cancer remains the second leading cause of death in the US, accounting for 25% of all
deaths nationwide. Immunotherapy techniques bolster the immune cells' ability to target …

Out of several heterocyclic templates, the use of a Benzimidazole (BZ) scaffold is immensely
observed. This fused heterocycle comprises two ring nitrogen atoms placed at 1st and 3rd …

Inborn Errors of Immunity (IEI) comprise more than 450 inherited diseases, from which
selected patients manifest a frequent and early incidence of malignancies, mainly lymphoma …

Background Essential thrombocythemia (ET) is one of the most common types of Ph-
negative myeloproliferative neoplasms, an infrequent group of blood cancers that arise from …

Patients with peripheral T-cell lymphomas generally have poor clinical outcomes with
conventional chemotherapy. Recent advances have demonstrated that a large subgroup of …

Background: Propofol induces acute neurotoxicity (eg, neuroapoptosis) followed by
impairment of long-term memory and learning in animals. However, underlying mechanisms …

Two of the deadliest infectious diseases, COVID-19 and tuberculosis (TB), have combined to
establish a worldwide pandemic, wreaking havoc on economies and claiming countless …