Helicobacter pylori infection and antibiotic resistance — from biology to clinical implications

E Tshibangu-Kabamba, Y Yamaoka - Nature Reviews Gastroenterology …, 2021 - nature.com
Helicobacter pylori is a major human pathogen for which increasing antibiotic resistance
constitutes a serious threat to human health. Molecular mechanisms underlying this …

Gastric cancer: advances in carcinogenesis research and new therapeutic strategies

L Seeneevassen, E Bessède, F Mégraud… - International journal of …, 2021 - mdpi.com
Gastric cancer's bad incidence, prognosis, cellular and molecular heterogeneity amongst
others make this disease a major health issue worldwide. Understanding this affliction is a …

The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

K Thorell, ZY Muñoz-Ramírez, D Wang… - Nature …, 2023 - nature.com
Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary
history with humans. This has led to the development of genetically distinct H. pylori …

[HTML][HTML] Helicobacter pylori virulence genes

A Šterbenc, E Jarc, M Poljak… - World journal of …, 2019 - ncbi.nlm.nih.gov
Helicobacter pylori (H. pylori) is one of the most important human pathogens, infecting
approximately half of the global population. Despite its high prevalence, only a subset of H …

Helicobacter pylori Virulence Factors Exploiting Gastric Colonization and its Pathogenicity

S Ansari, Y Yamaoka - Toxins, 2019 - mdpi.com
Helicobacter pylori colonizes the gastric epithelial cells of at least half of the world's
population, and it is the strongest risk factor for developing gastric complications like chronic …

Helicobacter pylori infection causes both protective and deleterious effects in human health and disease

AK Miller, SM Williams - Genes & Immunity, 2021 - nature.com
Infection with Helicobacter pylori (H. pylori) is necessary but not sufficient for the
development of gastric cancer, the third leading cause of cancer death globally. H. pylori …

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice

CM Smith, RE Baker, MK Proulx, BB Mishra, JE Long… - Elife, 2022 - elifesciences.org
The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

Next-generation microbiology: from comparative genomics to gene function

CM Kobras, AK Fenton, SK Sheppard - Genome Biology, 2021 - Springer
Microbiology is at a turning point in its 120-year history. Widespread next-generation
sequencing has revealed genetic complexity among bacteria that could hardly have been …

Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation

C Chaguza, JT Smith, SA Bruce, R Gibson, IW Martin… - Cell genomics, 2022 - cell.com
Staphylococcus aureus is a multi-host pathogen that causes infections in animals and
humans globally. The specific genetic loci—and the extent to which they drive cross-species …

Forest and trees: exploring bacterial virulence with genome-wide association studies and machine learning

JP Allen, E Snitkin, NB Pincus, AR Hauser - Trends in microbiology, 2021 - cell.com
The advent of inexpensive and rapid sequencing technologies has allowed bacterial whole-
genome sequences to be generated at an unprecedented pace. This wealth of information …