Radiotherapy (RT), including external beam RT and internal radiation therapy, uses high-
energy ionizing radiation to kill tumor cells. However, ionizing radiation inevitably damages …

Hypoxia is a unique characteristic of the solid tumor microenvironment. Hypoxia contributes
to multi-drug resistance, metastasis and cancer relapse through numerous molecular …

Microrobots driven by multiple propelling forces hold great potential for noninvasively
targeted delivery in the physiologic environment. However, the remotely collective …

Single-atom nanozyme (SAzyme) systems have shown great potential in tumor therapy. A
multifunctional SAzyme not only possesses high catalytic activity but also can be used as …

Replication stress (RS) induced by DNA damage plays a significant role in conferring the
anticancer effects of radiotherapy and is tightly associated with radioresistance of cancer …

Intestinal homeostasis is a dynamic balance involving the interaction between the host
intestinal mucosa, immune barrier, intestinal microecology, nutrients, and metabolites. Once …

Bacteria-mediated anti-tumor therapy has received widespread attention due to its natural
tumor-targeting ability and specific immune-activation characteristics. It has made significant …

Hypoxia is a prominent feature of malignant tumors and contributes to tumor proliferation,
metastasis, and drug resistance in various solid tumors. Therefore, improving tumor …

As natural living substances, microorganisms have emerged as useful resources in
medicine for creating microbe-material hybrids ranging from nano to macro dimensions. The …

Hypoxia in local tumors leads to the failure or resistance of radiotherapy (RT) and high-dose
RT will cause systemic reactions and local radiation damage. As a non-chemotherapeutic …