Pathophysiology and treatment of stroke: present status and future perspectives

D Kuriakose, Z Xiao - International journal of molecular sciences, 2020 - mdpi.com
Stroke is the second leading cause of death and a major contributor to disability worldwide.
The prevalence of stroke is highest in developing countries, with ischemic stroke being the …

Development of innovative biomaterials and devices for the treatment of cardiovascular diseases

Y Wang, G Li, L Yang, R Luo, G Guo - Advanced Materials, 2022 - Wiley Online Library
Cardiovascular diseases have become the leading cause of death worldwide. The
increasing burden of cardiovascular diseases has become a major public health problem …

Undulating changes in human plasma proteome profiles across the lifespan

B Lehallier, D Gate, N Schaum, T Nanasi, SE Lee… - Nature medicine, 2019 - nature.com
Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …

Glial cells: role of the immune response in ischemic stroke

S Xu, J Lu, A Shao, JH Zhang, J Zhang - Frontiers in immunology, 2020 - frontiersin.org
Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …

Stroke risk factors, genetics, and prevention

AK Boehme, C Esenwa, MSV Elkind - Circulation research, 2017 - Am Heart Assoc
Stroke is a heterogeneous syndrome, and determining risk factors and treatment depends
on the specific pathogenesis of stroke. Risk factors for stroke can be categorized as …

Erectile dysfunction and diabetes: A melting pot of circumstances and treatments

G Defeudis, R Mazzilli, M Tenuta… - Diabetes/metabolism …, 2022 - Wiley Online Library
Diabetes mellitus (DM), a chronic metabolic disease characterised by elevated levels of
blood glucose, is among the most common chronic diseases. The incidence and prevalence …

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

S Zhou, J Jin, J Wang, Z Zhang, JH Freedman… - Acta Pharmacologica …, 2018 - nature.com
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
world. Although considerable progress has been made in the diagnosis, treatment and …

The ancestral and industrialized gut microbiota and implications for human health

ED Sonnenburg, JL Sonnenburg - Nature Reviews Microbiology, 2019 - nature.com
Human-associated microbial communities have adapted to environmental pressures. Doses
of antibiotics select for a community with increased antibiotic resistance, inflammation is …

Role of the ACE2/angiotensin 1–7 axis of the renin–angiotensin system in heart failure

VB Patel, JC Zhong, MB Grant, GY Oudit - Circulation research, 2016 - Am Heart Assoc
Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

Sedentary behavior and cardiovascular morbidity and mortality: a science advisory from the American Heart Association

DR Young, MF Hivert, S Alhassan, SM Camhi… - Circulation, 2016 - Am Heart Assoc
Epidemiological evidence is accumulating that indicates greater time spent in sedentary
behavior is associated with all-cause and cardiovascular morbidity and mortality in adults …