CARM1/PRMT4: making its mark beyond its function as a transcriptional coactivator
Coactivator-associated arginine methyltransferase 1 (CARM1), identified 20 years ago as a
coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins …
coregulator of transcription, is an enzyme that catalyzes arginine methylation of proteins …
Biochemistry and regulation of the protein arginine methyltransferases (PRMTs)
Many key cellular processes can be regulated by the seemingly simple addition of one, or
two, methyl groups to arginine residues by the nine known mammalian protein arginine …
two, methyl groups to arginine residues by the nine known mammalian protein arginine …
[HTML][HTML] CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis
Coactivator-associated arginine methyltransferase 1 (CARM1), a coactivator for various
cancer-relevant transcription factors, is overexpressed in breast cancer. To elucidate the …
cancer-relevant transcription factors, is overexpressed in breast cancer. To elucidate the …
[HTML][HTML] Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine-and arginine-rich regions
The mammalian protein arginine methyltransferase 7 (PRMT7) has been implicated in roles
of transcriptional regulation, DNA damage repair, RNA splicing, cell differentiation, and …
of transcriptional regulation, DNA damage repair, RNA splicing, cell differentiation, and …
Arginine methylation‐dependent LSD1 stability promotes invasion and metastasis of breast cancer
Abstract Histone lysine demethylase 1 (LSD 1), the first identified histone demethylase, is
overexpressed in multiple tumor types, including breast cancer. However, the mechanisms …
overexpressed in multiple tumor types, including breast cancer. However, the mechanisms …
[HTML][HTML] The dystrophin glycoprotein complex regulates the epigenetic activation of muscle stem cell commitment
Asymmetrically dividing muscle stem cells in skeletal muscle give rise to committed cells,
where the myogenic determination factor Myf5 is transcriptionally activated by Pax7. This …
where the myogenic determination factor Myf5 is transcriptionally activated by Pax7. This …
[HTML][HTML] Role of PRMTs in cancer: Could minor isoforms be leaving a mark?
RM Baldwin, A Morettin, J Côté - World journal of biological …, 2014 - ncbi.nlm.nih.gov
Protein arginine methyltransferases (PRMTs) catalyze the methylation of a variety of protein
substrates, many of which have been linked to the development, progression and …
substrates, many of which have been linked to the development, progression and …
Role of histone-modifying enzymes and their complexes in regulation of chromatin biology
R DesJarlais, PJ Tummino - Biochemistry, 2016 - ACS Publications
In 1964, Alfrey and colleagues proposed that acetylation and methylation of histones may
regulate RNA synthesis and described “the possibility that relatively minor modifications of …
regulate RNA synthesis and described “the possibility that relatively minor modifications of …
[HTML][HTML] Protein arginine methylation in viral infection and antiviral immunity
K Zheng, S Chen, Z Ren, Y Wang - International journal of …, 2023 - ncbi.nlm.nih.gov
Protein arginine methyltransferase (PRMT)-mediated arginine methylation is an important
post-transcriptional modification that regulates various cellular processes including …
post-transcriptional modification that regulates various cellular processes including …
MED12 methylation by CARM1 sensitizes human breast cancer cells to chemotherapy drugs
The RNA polymerase II mediator complex subunit 12 (MED12) is frequently mutated in
human cancers, and loss of MED12 has been shown to induce drug resistance through …
human cancers, and loss of MED12 has been shown to induce drug resistance through …