Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both …

Cutaneous leishmaniasis (CL) is a public health problem affecting more than 98 countries
worldwide. No vaccine is available to prevent the disease, and available medical treatments …

Parasitic diseases remain as unresolved health issues worldwide. While for some parasites
the treatments involve drug combinations with serious side effects, for others, chemical …

American trypanosomiasis is a worldwide health problem that requires attention due to
ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1 …

Chagas disease is a disease that is emerging in North America and Europe countries.
Benznidazole is the main drug available, but it has high toxicity and low efficacy in the …

Chagas disease (CD) is a neglected tropical disease of worldwide health concern, caused
by the flagellate protozoan Trypanosoma cruzi (T. cruzi), endemic in Latin America and …

During three decades, only about 20 new drugs have been developed for malaria,
tuberculosis and all neglected tropical diseases (NTDs). This critical situation was reached …

The neglected infection known as Chagas disease, caused by the protozoan parasite
Trypanosoma cruzi, results in more than 7000 deaths per year, with an increasing number of …

Drug resistance is a core issue in cancer chemotherapy. A known folate antagonist,
methotrexate (MTX) inhibits human dihydrofolate reductase (hDHFR), the enzyme …