Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset
Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid …

Alzheimer's disease (AD) is a complex and heterogeneous neurodegenerative disorder,
classified as either early onset (under 65 years of age), or late onset (over 65 years of age) …

Alzheimer's disease is the most common type of dementia, and it is characterized by a
decline in memory or other thinking skills. The greatest risk factor for Alzheimer's disease is …

With the increase in life expectancy registered in the past few decades, the prevalence of
various medical conditions related to aging has been observed, such as dementia and …

Background: In addition to nonmodifiable genetic risk factors, potentially modifiable factors
such as hypertension, hyperlipidemia and environmental exposures have been identified as …

Mutations in presenilin 2 are rare causes of early onset familial Alzheimer's disease.
Eighteen presenilin 2 mutations have been reported, although not all have been confirmed …

Reduction and oxidation reactions are essential for biochemical processes. They are part of
metabolic pathways and signal transduction. Reactive oxygen species (ROS) as second …

Alzheimer's disease (AD) is the most common form of dementia. Mutations in the genes
encoding presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein have …

Alzheimer's disease (AD) genetics may be one of the most prolifically published areas in
medicine and biology. Three early-onset AD genes with causative mutations (APP, PSEN1 …

There are great diversities of clinical phenotypes among the various familial Alzheimer's
disease (FAD) families. We aimed to systematically review all the previously reported cases …