Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …

Macrophages are immune cells of haematopoietic origin that provide crucial innate immune
defence and have tissue-specific functions in the regulation and maintenance of organ …

Macrophages are the first cells of the nascent immune system to emerge during embryonic
development. In mice, embryonic macrophages infiltrate developing organs, where they …

Hematopoietic potential arises in mammalian embryos before adult-repopulating
hematopoietic stem cells (HSCs). At embryonic day 9.5 (E9. 5), we show the first murine …

The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has
remained controversial until recently. Originally described as part of the mononuclear …

Hematopoiesis–the process by which blood cells are formed–has been studied intensely for
over a century using a variety of model systems. There is conservation of the overall …

Barrier structures (for example, epithelia around tissues and plasma membranes around
cells) are required for internal homeostasis and protection from pathogens. Wound detection …

The zebrafish is a recent addition to animal models of human cancer, and studies using this
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Identifying signaling pathways that regulate hematopoietic stem and progenitor cell (HSPC)
formation in the embryo will guide efforts to produce and expand HSPCs ex vivo. Here we …