SLC family transporters
X Liu - Drug transporters in drug disposition, effects and …, 2019 - Springer
Solute carrier (SLC) family transporters utilize an electrochemical potential difference or an
ion gradient generated by primary active transporters for transporting their substrates across …
ion gradient generated by primary active transporters for transporting their substrates across …
Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy
T Nakanishi, I Tamai - Journal of pharmaceutical sciences, 2011 - Elsevier
Many solute carrier transporters that interact with anticancer agents and contribute to their
pharmacokinetics have been shown to be differentially upregulated in cancer cells as a …
pharmacokinetics have been shown to be differentially upregulated in cancer cells as a …
Development of a peptide–drug conjugate for prostate cancer therapy
TGX-221 is a highly potent phosphoinositide 3-kinase β (PI3Kβ) inhibitor that holds great
promise as a novel chemotherapeutic agent to treat prostate cancer. However, poor …
promise as a novel chemotherapeutic agent to treat prostate cancer. However, poor …
Expression profile and functional activity of peptide transporters in prostate cancer cells
Peptide transporters are expressed predominantly in intestinal and renal epithelial cells. The
functional expression of peptide transporters is also identified in other types of tissues, such …
functional expression of peptide transporters is also identified in other types of tissues, such …
Evaluation of anticancer activity in vitro of a stable copper (I) complex with phosphine-peptide conjugate
UK Komarnicka, B Pucelik, D Wojtala, MK Lesiów… - Scientific reports, 2021 - nature.com
Abstract [CuI (2, 9-dimethyl-1, 10-phenanthroline) P (p-OCH3-Ph) 2CH2SarcosineGlycine](1-
MPSG), highly stable in physiological media phosphino copper (I) complex—is proposed …
MPSG), highly stable in physiological media phosphino copper (I) complex—is proposed …
Imaging tumor metabolism using positron emission tomography
Positron emission tomography (PET) is an extraordinarily sensitive clinical imaging modality
for interrogating tumor metabolism. Radiolabeled PET substrates can be traced at …
for interrogating tumor metabolism. Radiolabeled PET substrates can be traced at …
Positron emission tomography imaging of prostate cancer
Prostate cancer (PCa) is the second leading cause of cancer death among men in the
United States. Positron emission tomography (PET), a non-invasive, sensitive, and …
United States. Positron emission tomography (PET), a non-invasive, sensitive, and …
Hijacking solute carriers for proton-coupled drug transport
CMH Anderson, DT Thwaites - Physiology, 2010 - journals.physiology.org
The physiological role of mammalian solute carrier (SLC) proteins is to mediate
transmembrane movement of electrolytes, nutrients, micronutrients, vitamins, and …
transmembrane movement of electrolytes, nutrients, micronutrients, vitamins, and …
Gold (III)-dithiocarbamato peptidomimetics in the forefront of the targeted anticancer therapy: Preclinical studies against human breast neoplasia
C Nardon, SM Schmitt, H Yang, J Zuo, D Fregona… - PloS one, 2014 - journals.plos.org
Since the serendipitous discovery of cisplatin, platinum-based drugs have become well-
established antitumor agents, despite the fact that their clinical use is limited by many severe …
established antitumor agents, despite the fact that their clinical use is limited by many severe …
Distinct metabolic differences between various human cancer and primary cells
Recent years have seen resurging interest in cancer cell metabolism and the role of
secreted cancer metabolites in modulating the tumor stroma. Using a combination of …
secreted cancer metabolites in modulating the tumor stroma. Using a combination of …