Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity
Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …
pharmacological interventions that are associated with poor adherence and adverse effects …
[HTML][HTML] Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering
Bone fractures are common in clinics and the demand for effective repair material is high.
Unfortunately, limited graft availability, donor site morbidities, unpredictable clinical …
Unfortunately, limited graft availability, donor site morbidities, unpredictable clinical …
Scaffolds for bone-tissue engineering
Due to a prolonged life expectancy, the number of orthopedic-related fractures and
pathologies is increasing, leading to a tremendous demand for efficient orthopedic …
pathologies is increasing, leading to a tremendous demand for efficient orthopedic …
Recent advances in BMP receptor signaling
Bone Morphogenetic Proteins (BMPs) play an important role during organ development and
during regeneration after tissue damage. BMPs signal via transmembrane serine/threonine …
during regeneration after tissue damage. BMPs signal via transmembrane serine/threonine …
Boning up on Wolff's Law: mechanical regulation of the cells that make and maintain bone
Bone tissue forms and is remodeled in response to the mechanical forces that it
experiences, a phenomenon described by Wolff's Law. Mechanically induced formation and …
experiences, a phenomenon described by Wolff's Law. Mechanically induced formation and …
[HTML][HTML] Differentiation of bone marrow mesenchymal stem cells in osteoblasts and adipocytes and its role in treatment of osteoporosis
C Wang, H Meng, X Wang, C Zhao… - … medical journal of …, 2016 - ncbi.nlm.nih.gov
Osteoporosis is a systemic metabolic bone disorder characterized by a decrease in bone
mass and degradation of the bone microstructure, leaving bones that are fragile and prone …
mass and degradation of the bone microstructure, leaving bones that are fragile and prone …
The use of injectable sonication-induced silk hydrogel for VEGF165 and BMP-2 delivery for elevation of the maxillary sinus floor
W Zhang, X Wang, S Wang, J Zhao, L Xu, C Zhu… - Biomaterials, 2011 - Elsevier
Sonication-induced silk hydrogels were previously prepared as an injectable bone
replacement biomaterial, with a need to improve osteogenic features. Vascular endothelial …
replacement biomaterial, with a need to improve osteogenic features. Vascular endothelial …
Improved cellular infiltration in electrospun fiber via engineered porosity
Small pore sizes inherent to electrospun matrices can hinder efficient cellular ingrowth. To
facilitate infiltration while retaining its extracellular matrix-like character, electrospinning was …
facilitate infiltration while retaining its extracellular matrix-like character, electrospinning was …
The use of auxetic materials in tissue engineering
P Mardling, A Alderson, N Jordan-Mahy… - Biomaterials …, 2020 - pubs.rsc.org
A number of biological tissues have been reported as behaving in an auxetic manner,
defined by a negative Poisson's ratio. This describes the deformation of tissue which …
defined by a negative Poisson's ratio. This describes the deformation of tissue which …
Mechanical loading increased BMP‐2 expression which promoted osteogenic differentiation of tendon‐derived stem cells
This study aimed to investigate the effect of repetitive tensile loading on the expression of
BMP‐2 and the effect of BMP‐2 on the osteogenic differentiation of tendon‐derived stem …
BMP‐2 and the effect of BMP‐2 on the osteogenic differentiation of tendon‐derived stem …