Rapid evaluation of new cytotoxic agents and biological response modifiers for therapy of
cancer and elucidation of their mechanisms of action require the use of relevant animal …

Stress can alter immunological, neurochemical and endocrinological functions, but its role in
cancer progression is not well understood. Here, we show that chronic behavioral stress …

The mechanistic basis of a metastatic cell's ability to proliferate in the parenchyma of certain
organs and develop organ-specific metastases is under intense investigation. Signals from …

Epidermal growth factor receptor (EGFR) regulates the growth and progression of human
transitional cell carcinoma (TCC) of the bladder. We have shown that therapy targeting …

We determined whether the implantation of human pancreatic cancer cells into the pancreas
of nude mice can be used to select variants with increasing metastatic potential. COLO 357 …

Abstract Interleukin 8 (IL-8) is mitogenic and chemotactic for endothelial cells. Within a
neoplasm, IL-8 is secreted by inflammatory and neoplastic cells. The highly metastatic PC …

Neuropilin-1 (NRP1) is a 130-kDa transmembrane receptor for semaphorins, mediators of
neuronal guidance, and for vascular endothelial growth factor 165 (VEGF165), an …

BACKGROUND An epidermal growth factor receptor (EGFR) immunohistochemical
detection system currently is being developed. The current study attempts to address …

We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha,-beta, and-
gamma) on the production of basic fibroblast growth factor (bFGF) by human renal …

Background: By the time patients are diagnosed with ovarian carcinoma, peritoneal
dissemination of the tumor often has occurred. The progressive growth and spread of …