Patients with diabetes mellitus have> 2× the risk for developing heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

Chronic or intermittent hyperglycemia is associated with the development of diabetic
complications. Several signaling pathways can be altered by having hyperglycemia in …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular
processes, including protein synthesis, cellular growth, proliferation, autophagy, lysosomal …

Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

The release of reactive oxygen species (ROS) and the generation of oxidative stress are
considered critical factors for the pathogenesis of diabetes mellitus (DM), a disorder that is …

Diabetic cardiomyopathy is a heart muscle-specific disease that increases the risk of heart
failure and mortality in diabetic patients independent of vascular pathology. Mitochondria …

Aging can not only shorten a healthy lifespan, but can also lead to multi-organ dysfunction
and failure. Anti-aging is a complex and worldwide conundrum for eliminating the various …

With research progress on longevity, we have gradually recognized that cardiac aging
causes changes in heart structure and function, including progressive myocardial …