Antibodies are proteins that recognize the molecular surfaces of potentially noxious
molecules to mount an adaptive immune response or, in the case of autoimmune diseases …

Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals
despite significant challenges and risks to their discovery and development. This review …

Protein aggregation is a topic of immense interest to the scientific community due to its role
in several neurodegenerative diseases/disorders and industrial importance. Several in silico …

The light chain (AL) amyloidosis is caused by the aggregation of light chain of antibodies
into amyloid fibrils. There are plenty of computational resources available for the prediction …

Therapeutic protein, represented by antibodies, is of increasing interest in human medicine.
However, clinical translation of therapeutic protein is still largely hindered by different …

Cardiac amyloidosis is an uncommon restrictive cardiomyopathy featuring an unregulated
amyloid protein deposition that impairs organic function. Early cardiac amyloidosis …

Abstract The Curated Protein Aggregation Database (CPAD) is a manually curated and
open-access database dedicated to providing comprehensive information related to …

The prolonged transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) virus in the human population has led to demographic divergence and the …

Aggregation can be selectively induced by aggregation-prone regions (APRs) contained in
the target proteins. Aggregation-inducing antimicrobial peptides (Pept-ins) contain …

Abstract Background 2′-O-methylation (2′-O-me or Nm) is a post-transcriptional RNA
methylation modified at 2′-hydroxy, which is common in mRNAs and various non-coding …