[HTML][HTML] Cancer immunotherapy: Pros, cons and beyond

S Tan, D Li, X Zhu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cancer immunotherapy is an innovative treatment for tumors today. In various experiments
and clinical studies, it has been found that immunotherapy does have incomparable …

The importance of exosomal PDL1 in tumour immune evasion

D Daassi, KM Mahoney, GJ Freeman - Nature Reviews Immunology, 2020 - nature.com
The interaction of programmed cell death 1 ligand 1 (PDL1) with its receptor programmed
cell death 1 (PD1) inhibits T cell responses, and blockade of this interaction has proven to …

Gamma delta T-cell-based immune checkpoint therapy: attractive candidate for antitumor treatment

Z Gao, Y Bai, A Lin, A Jiang, C Zhou, Q Cheng, Z Liu… - Molecular Cancer, 2023 - Springer
As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of
immunotherapy in recent years. They have extraordinary antitumor potential and prospects …

Biological characteristics and clinical significance of soluble PD-1/PD-L1 and exosomal PD-L1 in cancer

M Niu, Y Liu, M Yi, D Jiao, K Wu - Frontiers in Immunology, 2022 - frontiersin.org
The immune checkpoint pathway consisting of the cell membrane-bound molecule
programmed death protein 1 (PD-1) and its ligand PD-L1 has been found to mediate …

Beyond the anti-PD-1/PD-L1 era: promising role of the BTLA/HVEM axis as a future target for cancer immunotherapy

C Sordo-Bahamonde, S Lorenzo-Herrero… - Molecular Cancer, 2023 - Springer
Recent introduction of monoclonal antibodies targeting immune checkpoints to harness
antitumor immunity has revolutionized the cancer treatment landscape. The therapeutic …

Soluble PD-1: predictive, prognostic, and therapeutic value for cancer immunotherapy

M Khan, Z Zhao, S Arooj, Y Fu, G Liao - Frontiers in immunology, 2020 - frontiersin.org
Programmed death protein 1 (PD-1) interaction with PD-L1 deliver immunosuppressive
environment for tumor growth, and its blockade with directed monoclonal antibodies (anti …

The immune checkpoint PD-1 in natural killer cells: expression, function and targeting in tumour immunotherapy

L Quatrini, FR Mariotti, E Munari, N Tumino, P Vacca… - Cancers, 2020 - mdpi.com
Simple Summary Natural killer cells are innate cytotoxic lymphocytes that play a key role in
the anti-tumor immune response. In the tumor microenvironment, however, the effector …

Soluble B7-CD28 family inhibitory immune checkpoint proteins and anti-cancer immunotherapy

M Khan, S Arooj, H Wang - Frontiers in Immunology, 2021 - frontiersin.org
Co-inhibitory B7-CD28 family member proteins negatively regulate T cell responses and are
extensively involved in tumor immune evasion. Blockade of classical CTLA-4 (cytotoxic T …

[HTML][HTML] The molecular profiling of solid tumors by liquid biopsy: A position paper of the AIOM–SIAPEC-IAP–SIBioC–SIC–SIF Italian Scientific Societies

A Russo, L Incorvaia, M Del Re, U Malapelle… - ESMO open, 2021 - Elsevier
The term liquid biopsy (LB) refers to the use of various biological fluids as a surrogate for
neoplastic tissue to achieve information for diagnostic, prognostic and predictive purposes …

Programmed death ligand 1 (PD-L1) as a predictive biomarker for pembrolizumab therapy in patients with advanced non-small-cell lung cancer (NSCLC)

L Incorvaia, D Fanale, G Badalamenti, N Barraco… - Advances in …, 2019 - Springer
Recently, immunotherapy has been shown to be an effective and helpful therapeutic option
for the treatment of advanced non-small-cell lung cancer (NSCLC). The activity of antitumor …