Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …

During sepsis, the importance of alterations in cell metabolism is underappreciated. The
cellular metabolism, which has a variable metabolic profile in different cells and disease …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Sepsis pathogenesis is complex and heterogeneous; hence, a precision-medicine strategy
is needed. Acute kidney injury (AKI) following sepsis portends higher mortality …

Sepsis has evolved as an enormous health issue amongst critically ill patients. It is a major
risk factor that results in multiple organ failure and shock. Acute kidney injury (AKI) is one of …

Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity
and mortality in intensive care units. Current treatments for septic AKI are largely supportive …

Sepsis is now defined as a life-threatening syndrome of organ dysfunction triggered by a
dysregulated host response to infection, posing significant challenges in critical care. The …

The receptor-interacting protein kinase 3 (RIP3) has been reported to regulate programmed
necrosis–necroptosis forms of cell death with important functions in inflammation. We …

Mitochondria are key structures providing most of the energy needed to maintain
homeostasis. They are the main source of adenosine triphosphate (ATP), participate in …