Introducing protein intrinsic disorder
Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …
Advanced techniques for detecting protein misfolding and aggregation in cellular environments
Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …
Developing a molecular dynamics force field for both folded and disordered protein states
Molecular dynamics (MD) simulation is a valuable tool for characterizing the structural
dynamics of folded proteins and should be similarly applicable to disordered proteins and …
dynamics of folded proteins and should be similarly applicable to disordered proteins and …
A synergy between site-specific and transient interactions drives the phase separation of a disordered, low-complexity domain
TAR DNA-binding protein 43 (TDP-43) is involved in key processes in RNA metabolism and
is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral …
is frequently implicated in many neurodegenerative diseases, including amyotrophic lateral …
Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2
The AlphaFold Protein Structure Database contains predicted structures for millions of
proteins. For the majority of human proteins that contain intrinsically disordered regions …
proteins. For the majority of human proteins that contain intrinsically disordered regions …
Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
Membrane encapsulation is frequently used by the cell to sequester biomolecules and
compartmentalize their function. Cells also concentrate molecules into phase-separated …
compartmentalize their function. Cells also concentrate molecules into phase-separated …
Mechanistic view of hnRNPA2 low-complexity domain structure, interactions, and phase separation altered by mutation and arginine methylation
Summary hnRNPA2, a component of RNA-processing membraneless organelles, forms
inclusions when mutated in a syndrome characterized by the degeneration of neurons …
inclusions when mutated in a syndrome characterized by the degeneration of neurons …
Ubiquitin modulates liquid-liquid phase separation of UBQLN2 via disruption of multivalent interactions
TP Dao, RM Kolaitis, HJ Kim, K O'Donovan… - Molecular cell, 2018 - cell.com
Under stress, certain eukaryotic proteins and RNA assemble to form membraneless
organelles known as stress granules. The most well-studied stress granule components are …
organelles known as stress granules. The most well-studied stress granule components are …
Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour
Abstract α-synuclein (αS) is a protein involved in neurotransmitter release in presynaptic
terminals, and whose aberrant aggregation is associated with Parkinson's disease. In …
terminals, and whose aberrant aggregation is associated with Parkinson's disease. In …
Residue-by-residue view of in vitro FUS granules that bind the C-terminal domain of RNA polymerase II
Phase-separated states of proteins underlie ribonucleoprotein (RNP) granules and nuclear
RNA-binding protein assemblies that may nucleate protein inclusions associated with …
RNA-binding protein assemblies that may nucleate protein inclusions associated with …