Traumatic brain injury and risk of neurodegenerative disorder

BL Brett, RC Gardner, J Godbout, K Dams-O'Connor… - Biological …, 2022 - Elsevier
Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …

The good, the bad, and the opportunities of the complement system in neurodegenerative disease

ND Schartz, AJ Tenner - Journal of Neuroinflammation, 2020 - Springer
The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …

Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia

KG Witcher, CE Bray, T Chunchai, F Zhao… - Journal of …, 2021 - Soc Neuroscience
Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and
neurodegenerative pathologies, which develop and persist years after injury …

Traumatic brain injury: mechanisms of glial response

RG Mira, M Lira, W Cerpa - Frontiers in physiology, 2021 - frontiersin.org
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …

Uncovering sex differences of rodent microglia

J Han, Y Fan, K Zhou, K Blomgren… - Journal of …, 2021 - Springer
There are inherent structural and functional differences in the central nervous systems
(CNS) of females and males. It has been gradually established that these sex-specific …

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

RJ Henry, RM Ritzel, JP Barrett, SJ Doran… - Journal of …, 2020 - Soc Neuroscience
Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …

[HTML][HTML] Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis

AC Bolte, AB Dutta, ME Hurt, I Smirnov… - Nature …, 2020 - nature.com
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we
demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause …

[HTML][HTML] Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in …

Y Li, RM Ritzel, N Khan, T Cao, J He, Z Lei… - Theranostics, 2020 - ncbi.nlm.nih.gov
Neuropsychological deficits, including impairments in learning and memory, occur after
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …

Plasticity of microglia

M Augusto‐Oliveira, GP Arrifano, CI Delage… - Biological …, 2022 - Wiley Online Library
Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …

Neuroinflammation following traumatic brain injury: take it seriously or not

R Zheng, K Lee, Z Qi, Z Wang, Z Xu, X Wu… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …