Traumatic brain injury and risk of neurodegenerative disorder
Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …
The good, the bad, and the opportunities of the complement system in neurodegenerative disease
ND Schartz, AJ Tenner - Journal of Neuroinflammation, 2020 - Springer
The complement cascade is a critical effector mechanism of the innate immune system that
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …
contributes to the rapid clearance of pathogens and dead or dying cells, as well as …
Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia
KG Witcher, CE Bray, T Chunchai, F Zhao… - Journal of …, 2021 - Soc Neuroscience
Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and
neurodegenerative pathologies, which develop and persist years after injury …
neurodegenerative pathologies, which develop and persist years after injury …
Traumatic brain injury: mechanisms of glial response
Traumatic brain injury (TBI) is a heterogeneous disorder that involves brain damage due to
external forces. TBI is the main factor of death and morbidity in young males with a high …
external forces. TBI is the main factor of death and morbidity in young males with a high …
Uncovering sex differences of rodent microglia
J Han, Y Fan, K Zhou, K Blomgren… - Journal of …, 2021 - Springer
There are inherent structural and functional differences in the central nervous systems
(CNS) of females and males. It has been gradually established that these sex-specific …
(CNS) of females and males. It has been gradually established that these sex-specific …
Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits
Chronic neuroinflammation with sustained microglial activation occurs following severe
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …
traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration …
[HTML][HTML] Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
AC Bolte, AB Dutta, ME Hurt, I Smirnov… - Nature …, 2020 - nature.com
Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we
demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause …
demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause …
[HTML][HTML] Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in …
Neuropsychological deficits, including impairments in learning and memory, occur after
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …
spinal cord injury (SCI). In experimental SCI models, we and others have reported that such …
Plasticity of microglia
Microglial cells are the scions of foetal macrophages which invade the neural tube early
during embryogenesis. The nervous tissue environment instigates the phenotypic …
during embryogenesis. The nervous tissue environment instigates the phenotypic …
Neuroinflammation following traumatic brain injury: take it seriously or not
R Zheng, K Lee, Z Qi, Z Wang, Z Xu, X Wu… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …
socioeconomic burden. With the standardization of the treatment process, there is increasing …