Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Myofibrillar myopathies (MFMs) represent a group of muscular dystrophies with a similar
morphological phenotype. The diagnosis is established by muscle biopsy. The MFMs are …

Sarcomeres are force-generating and load-bearing devices of muscles. A precise molecular
picture of how sarcomeres are built underpins understanding their role in health and …

Abstract Objective Myofibrillar myopathies (MFMs) are morphologically distinct but
genetically heterogeneous muscular dystrophies in which disintegration of Z disks and then …

Cardiac disease is a common clinical manifestation of neuromuscular disorders, particularly
of muscular dystrophies. Heart muscle cells as well as specialized conducting myocardial …

Objective: To compare muscle imaging findings in different subtypes of myofibrillar
myopathies (MFM) in order to identify characteristic patterns of muscle alterations that may …

Objective: To estimate the prevalence rates (PRs) of acquired and inherited neuromuscular
diseases (NMD) in the adult Irish population, reflecting the burden of these conditions in a …

Hereditary muscular diseases commonly involve the heart. Cardiac manifestations
encompass a spectrum of phenotypes, including both cardiomyopathies and rhythm …

Costameres are sub-membranous, Z-line associated structures found in striated muscle.
They have been shown to have important roles in transmission of force from the sarcomere …

The Z-disc acts as a protein-rich structure to tether thin filament in the contractile units, the
sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining …