Challenges in the elimination of pediatric HIV-1 infection

K Luzuriaga, LM Mofenson - New England Journal of Medicine, 2016 - Mass Medical Soc
Challenges in the Elimination of Pediatric HIV-1 Infection | New England Journal of Medicine
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Immunopathogenesis and immunotherapy in AIDS virus infections

NL Letvin, BD Walker - Nature medicine, 2003 - nature.com
The heterogeneity of HIV and the different human leukocyte antigen (HLA) backgrounds of
infected individuals have posed challenges to understanding the pathogenesis of HIV …

Absence of detectable HIV-1 viremia after treatment cessation in an infant

D Persaud, H Gay, C Ziemniak, YH Chen… - … England Journal of …, 2013 - Mass Medical Soc
An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection
began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure …

Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient

SA Yukl, E Boritz, M Busch, C Bentsen, TW Chun… - PLoS …, 2013 - journals.plos.org
There is intense interest in developing curative interventions for HIV. How such a cure will
be quantified and defined is not known. We applied a series of measurements of HIV …

Immunology of pediatric HIV infection

NH Tobin, GM Aldrovandi - Immunological reviews, 2013 - Wiley Online Library
Most infants born to human immunodeficiency virus (HIV)‐infected women escape HIV
infection. Infants evade infection despite an immature immune system and, in the case of …

HIV type 1 (HIV-1) Proviral reservoirs decay continuously under sustained Virologic control in HIV-1–infected children who received early treatment

K Luzuriaga, B Tabak, M Garber… - The Journal of …, 2014 - academic.oup.com
Background. Early initiation of combination antiretroviral therapy (cART) to human
immunodeficiency virus type 1 (HIV-1)–infected infants controls HIV-1 replication and …

Timing of HAART defines the integrity of memory B cells and the longevity of humoral responses in HIV-1 vertically-infected children

S Pensieroso, A Cagigi, P Palma… - Proceedings of the …, 2009 - National Acad Sciences
HIV-1 infection induces a progressive disruption of the B cell compartment impairing long-
term immune responses to routine immunizations. Depletion of specific memory B cell pools …

Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection

DB Lewis, JH Weitkamp, O Levy - … and Klein's Infectious Diseases of the …, 2025 - Elsevier
The human fetus and neonate are unduly susceptible to infection with a number of bacterial,
fungal, protozoal, and viral agents, many of which are not pathogenic in older children and …

A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation

A Violari, MF Cotton, L Kuhn, DB Schramm… - Nature …, 2019 - nature.com
Understanding HIV remission in rare individuals who initiated antiretroviral therapy (ART)
soon after infection and then discontinued, may inform HIV cure interventions. Here we …

International perspectives, progress, and future challenges of paediatric HIV infection

A Prendergast, G Tudor-Williams, P Jeena, S Burchett… - The Lancet, 2007 - thelancet.com
Paediatric HIV infection is a growing health challenge worldwide, with an estimated 1500
new infections every day. In developed countries, well established prevention programmes …