Surface Bio‐engineered Polymeric Nanoparticles

LL Haidar, M Bilek, B Akhavan - Small, 2024 - Wiley Online Library
Surface bio‐engineering of polymeric nanoparticles (PNPs) has emerged as a cornerstone
in contemporary biomedical research, presenting a transformative avenue that can …

Innovative vaccine platforms against infectious diseases: Under the scope of the COVID-19 pandemic

M Tsakiri, N Naziris, C Demetzos - International Journal of Pharmaceutics, 2021 - Elsevier
While classic vaccines have proved greatly efficacious in eliminating serious infectious
diseases, innovative vaccine platforms open a new pathway to overcome dangerous …

Co-assembled nanocomplexes of peptide neoantigen Adpgk and Toll-like receptor 9 agonist CpG ODN for efficient colorectal cancer immunotherapy

Z Liang, X Cui, L Yang, Q Hu, D Li, X Zhang… - International Journal of …, 2021 - Elsevier
Cancer vaccines targeting tumor specific neoantigens derived from nonsynonymous
mutations of tumor cells have emerged as an effective approach to induce antitumor T cells …

A novel self-assembled epitope peptide nanoemulsion vaccine targeting nasal mucosal epithelial cell for reinvigorating CD8+ T cell immune activity and inhibiting …

Y Yang, S Ge, Z Song, A Zhao, L Zhao, Z Hu… - International journal of …, 2021 - Elsevier
Epitope peptides are not suitable for nasal administration immunity due to their poor
immunogenicity and low delivery efficiency. Here, we reported an intranasal self-assembled …

Application of nanoscale metal–organic frameworks in tumor immunotherapy

XX Zeng, JS Lu, DW Ma, YT Huang, L Chen, G Wang… - Rare Metals, 2024 - Springer
Immunotherapy has attracted wide attention because it can not only kill tumor cells but also
effectively prevent tumor recurrence. However, due to the poor efficacy of the monotherapy …

[HTML][HTML] Early-Stage IM Treatment with the Host-Derived Immunostimulant CPDI-02 Increases Curative Protection of Healthy Outbred Mice Against Subcutaneous …

JP Stewart, CM Sandall, JE Parriott, SM Curran… - Pharmaceutics, 2024 - mdpi.com
Background/Objectives: Community-acquired methicillin-resistant Staphylococcus aureus
(CA-MRSA) greatly complicates the treatment of skin and soft tissue infections (SSTI). It was …

Surface modification of biodegradable microparticles with the novel host-derived immunostimulant CPDI-02 significantly increases short-term and long-term mucosal …

JE Parriott, JP Stewart, DD Smith, SM Curran… - Pharmaceutics, 2022 - mdpi.com
Generating long-lived mucosal and systemic antibodies through respiratory immunization
with protective antigens encapsulated in nanoscale biodegradable particles could …

Adjuvants for Vaccines

JP Stewart, JA Vetro - Neuroimmune Pharmacology and Therapeutics, 2024 - Springer
This chapter highlights the general characteristics of pathogen-and host-derived adjuvants,
their advantages and disadvantages, and their contribution to adaptive immunity. An …

Targeted amino acid substitution overcomes scale-up challenges with the human C5a-derived decapeptide immunostimulant EP67

AM Alshammari, DD Smith, J Parriott… - ACS infectious …, 2020 - ACS Publications
EP67 is a second-generation, human C5a-derived decapeptide agonist of C5a receptor 1
(C5aR1/CD88) that selectively activates mononuclear phagocytes over neutrophils to …

Applications of nanoengineered therapeutics and vaccines: special emphasis on COVID-19

NK Mohamed, MA Hamad, AH Ghaleb, G Esmat… - … Effects of Nanomaterials, 2022 - Elsevier
Nanomedicine provides innovative strategies that had significantly improved drug and gene
delivery and allowed control over the engineering of therapeutics, diagnostics, vaccines …