[HTML][HTML] Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells
L Lin, J Couturier, X Yu, MA Medina, CA Kozinetz… - BMC immunology, 2014 - Springer
Abstract Background Granzyme B (GrzB) is a serine proteinase expressed by memory T
cells and NK cells. Methods to measure GrzB protein usually involve intracellular (flow …
cells and NK cells. Methods to measure GrzB protein usually involve intracellular (flow …
The TB-specific CD4+ T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans
BR Mothé, CSL Arlehamn, C Dow, MBC Dillon… - Tuberculosis, 2015 - Elsevier
Non-human primate (NHP) models of tuberculosis (TB) immunity and pathogenesis,
especially rhesus and cynomolgus macaques, are particularly attractive because of the high …
especially rhesus and cynomolgus macaques, are particularly attractive because of the high …
[PDF][PDF] Multifunctional analysis of CD4+ T-cell response as immune-based model for tuberculosis detection
M Lichtner, C Mascia, I Sauzullo, F Mengoni… - J Immunol …, 2015 - downloads.hindawi.com
Mono-and multifunctional specific CD4+ and CD8+ T-cell responses were evaluated to
improve the immune-based detection of active tuberculosis (TB) and latent infection (LTBI) …
improve the immune-based detection of active tuberculosis (TB) and latent infection (LTBI) …
CD69 flow cytometry to complement interferon‐γ release assay for active tuberculosis
Y Kim, MH Han, SW Kim, DI Won - Cytometry Part B: Clinical …, 2022 - Wiley Online Library
Background The interferon‐γ (IFN‐γ) release assay (IGRA) is widely used to diagnose
tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb). However, indeterminate …
tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb). However, indeterminate …
CD137 is a Useful Marker for Identifying CD4+ T Cell Responses to Mycobacterium tuberculosis
Z Yan, X Zheng, L Yi, J Wang, X Wang… - Scandinavian …, 2017 - Wiley Online Library
Upregulation of CD 137 on recently activated CD 8+ T cells has been used to identify rare
viral and tumour antigen‐specific T cells from the peripheral blood. We aimed to evaluate …
viral and tumour antigen‐specific T cells from the peripheral blood. We aimed to evaluate …
Comparative analysis of whole‐blood interferon‐γ and flow cytometry assays for detecting post‐treatment immune responses in patients with active tuberculosis
Background Intracellular cytokine flow cytometry (ICCFC) has been explored to detect
tuberculosis (TB) infections; however, there are little data regarding its use to examine the …
tuberculosis (TB) infections; however, there are little data regarding its use to examine the …
Multi-functional flow cytometry analysis of CD4+ T cells as an immune biomarker for latent tuberculosis status in patients treated with tumour necrosis factor (TNF) …
I Sauzullo, R Scrivo, F Mengoni… - Clinical & …, 2014 - academic.oup.com
Although monitoring tuberculosis (TB) infection during long-term treatment with tumour
necrosis factor (TNF) antagonists is of great importance, no monitoring strategy has yet …
necrosis factor (TNF) antagonists is of great importance, no monitoring strategy has yet …
Comparison of whole-blood interferon-γ assay and flow cytometry for the detection of tuberculosis infection
OBJECTIVE: Limited data exist about the performance of the intracellular cytokine flow
cytometry (ICCFC) with respect to that of the commercial interferon-γ release assay for the …
cytometry (ICCFC) with respect to that of the commercial interferon-γ release assay for the …
Treatment of latent tuberculosis infection induces changes in multifunctional Mycobacterium tuberculosis-specific CD4+ T cells
I Sauzullo, F Mengoni, C Mascia, R Rossi… - Medical microbiology …, 2016 - Springer
To ascertain whether multiparametric flow cytometry assessment of multifunctional
Mycobacterium tuberculosis (Mtb)-specific CD4+ and CD8+ T cells can distinguish between …
Mycobacterium tuberculosis (Mtb)-specific CD4+ and CD8+ T cells can distinguish between …
Rv2204c, Rv0753c and Rv0009 antigens specific T cell responses in latent and active TB–a flow cytometry-based analysis
High global prevalence of latent TB infection (LTBI) is a key challenge in distinguishing
patients with active pulmonary TB (PTB) from those with LTBI. The functional profile of CD4+ …
patients with active pulmonary TB (PTB) from those with LTBI. The functional profile of CD4+ …