Drug development of MET inhibitors: targeting oncogene addiction and expedience
The MET tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and
angiogenesis, thereby acting as a powerful expedient for cancer dissemination. MET can …
angiogenesis, thereby acting as a powerful expedient for cancer dissemination. MET can …
c-MET as a potential therapeutic target and biomarker in cancer
The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …
Collagen density promotes mammary tumor initiation and progression
PP Provenzano, DR Inman, KW Eliceiri, JG Knittel… - BMC medicine, 2008 - Springer
Background Mammographically dense breast tissue is one of the greatest risk factors for
developing breast carcinoma. Despite the strong clinical correlation, breast density has not …
developing breast carcinoma. Despite the strong clinical correlation, breast density has not …
Gene expression profiling of breast cell lines identifies potential new basal markers
E Charafe-Jauffret, C Ginestier, F Monville, P Finetti… - Oncogene, 2006 - nature.com
A better molecular characterization of breast cell lines (BCL) may help discover new markers
to apply to tumour samples. We performed gene and protein expression profiling of 31 BCL …
to apply to tumour samples. We performed gene and protein expression profiling of 31 BCL …
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non–small cell lung cancer
PC Ma, R Jagadeeswaran, S Jagadeesh… - Cancer research, 2005 - AACR
Non–small cell lung cancer (NSCLC) is a difficult disease to treat. The c-Met receptor is an
attractive potential target for novel therapeutic inhibition in human cancers. We provide …
attractive potential target for novel therapeutic inhibition in human cancers. We provide …
A list of candidate cancer biomarkers for targeted proteomics
M Polanski, NL Anderson - Biomarker insights, 2006 - journals.sagepub.com
We have compiled from literature and other sources a list of 1261 proteins believed to be
differentially expressed in human cancer. These proteins, only some of which have been …
differentially expressed in human cancer. These proteins, only some of which have been …
[HTML][HTML] Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species
Recent pregnancy correlates with decreased survival for breast cancer patients compared
with non–pregnancy-associated breast cancer. We hypothesize that postpartum mammary …
with non–pregnancy-associated breast cancer. We hypothesize that postpartum mammary …
Lymphangiogenesis and lymphatic metastasis in breast cancer
S Ran, L Volk, K Hall, MJ Flister - Pathophysiology, 2010 - Elsevier
Lymphatic metastasis is the main prognostic factor for survival of patients with breast cancer
and other epithelial malignancies. Mounting clinical and experimental data suggest that …
and other epithelial malignancies. Mounting clinical and experimental data suggest that …
Cell surface–anchored serine proteases in cancer progression and metastasis
CE Martin, K List - Cancer and Metastasis Reviews, 2019 - Springer
Over the last two decades, a novel subgroup of serine proteases, the cell surface–anchored
serine proteases, has emerged as an important component of the human degradome, and …
serine proteases, has emerged as an important component of the human degradome, and …
The possible correlation of Notch-1 and Notch-2 with clinical outcome and tumour clinicopathological parameters in human breast cancer
Abstract The Notch-1 and Notch-2 receptors play crucial roles in cell fate determination
through interaction with the Delta/Serrate/Lag-2 family of ligands. The function of Notch …
through interaction with the Delta/Serrate/Lag-2 family of ligands. The function of Notch …