The clinical team attending to a patient upon a diagnosis is faced with two main questions:
what treatment, and at what dose? Clinical trials' results provide the basis for guidance and …

Cells are the fundamental building blocks of life. Changes within a cell can propagate
throughout much larger, more complex systems. The knowledge of how these changes arise …

The recent emergence of antimicrobial resistance has become a major concern for
worldwide policy makers as very few new antibiotics have been developed in the last twenty …

Microfluidics is a technology that operates with small amounts of fluids and makes possible
the investigation of cells, enzymes, and biomolecules and encapsulation of biocatalysts in a …

Recent meta-analyses of genome-wide association studies identified a number of genetic
risk factors of Alzheimer's disease; however, little is known about the mechanisms by which …

Myelination is governed by neuron–glia communication, which in turn is modulated by
neural activity. The exact mechanisms remain elusive. We developed a novel in vitro …

Micro/nanofluidic drug delivery systems have attracted significant attention as they offer
unique advantages in targeted and controlled drug delivery. Based on the desired …

Natural products are still the principal source of drug candidates or leading compounds in
new drug discovery. It is an important challenge to innovate and construct a rapid and …

Research and development of innovative targeted therapies is a great challenge in the fight
against cancer. Although many treatment methods are currently available, there is no simple …

Screening drug combinations using tumor spheroids can play a vital role in the development
of disease treatment and personalized medicine. However, current studies focus on drug …