The effects of aging in the hippocampus and cognitive decline

LEB Bettio, L Rajendran, J Gil-Mohapel - Neuroscience & Biobehavioral …, 2017 - Elsevier
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer's disease

L Forny-Germano, FG De Felice… - Frontiers in …, 2019 - frontiersin.org
Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin

SY Yau, A Li, RLC Hoo, YP Ching… - Proceedings of the …, 2014 - National Acad Sciences
Adiponectin (ADN) is an adipocyte-secreted protein with insulin-sensitizing, antidiabetic,
antiinflammatory, and antiatherogenic properties. Evidence is also accumulating that ADN …

Adiponectin receptor signalling in the brain

J Thundyil, D Pavlovski, CG Sobey… - British journal of …, 2012 - Wiley Online Library
Adiponectin is an important adipocyte‐derived hormone that regulates metabolism of lipids
and glucose, and its receptors (AdipoR1, AdipoR2, T‐cadherin) appear to exert actions in …

Obesity and dementia: adipokines interact with the brain

IAC Arnoldussen, AJ Kiliaan, DR Gustafson - European …, 2014 - Elsevier
Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for
multiple conditions and contributes to multi-morbidities, resulting in increased health costs …

Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity

KH Chan, KSL Lam, OY Cheng, JSC Kwan, PWL Ho… - PloS one, 2012 - journals.plos.org
Beta-amyloid (Aβ) neurotoxicity is important in Alzheimer's disease (AD) pathogenesis. Aβ
neurotoxicity causes oxidative stress, inflammation and mitochondrial damage resulting in …

Neuroactive peptides as putative mediators of antiepileptic ketogenic diets

C Giordano, M Marchiò, E Timofeeva… - Frontiers in neurology, 2014 - frontiersin.org
Various ketogenic diet (KD) therapies, including classic KD, medium chain triglyceride
administration, low glycemic index treatment, and a modified Atkins diet, have been …

Physiological role of adiponectin in different tissues: a review

S Esmaili, M Hemmati, M Karamian - Archives of physiology and …, 2020 - Taylor & Francis
Adiponectin is the most important adipokine secreted by the adipose tissue. It carries out an
important role in setting up the metabolism and improving the function of various organs …

Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity

I Amigo, SL Menezes‐Filho, LA Luévano‐Martínez… - Aging cell, 2017 - Wiley Online Library
Caloric restriction (CR) protects against many cerebral pathological conditions that are
associated with excitotoxic damage and calcium overload, although the mechanisms are still …

Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines

L Letra, I Santana, R Seiça - Metabolic brain disease, 2014 - Springer
Alzheimer's disease is the leading cause of dementia and the most prevalent
neurodegenerative disease. It is an aging-related multi-factorial disorder and growing …