The effects of aging in the hippocampus and cognitive decline
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …
social impairments. One structure of particular interest when considering aging and …
The role of leptin and adiponectin in obesity-associated cognitive decline and Alzheimer's disease
L Forny-Germano, FG De Felice… - Frontiers in …, 2019 - frontiersin.org
Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …
increased risk of obese people to develop brain diseases such as cognitive and mood …
Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin
Adiponectin (ADN) is an adipocyte-secreted protein with insulin-sensitizing, antidiabetic,
antiinflammatory, and antiatherogenic properties. Evidence is also accumulating that ADN …
antiinflammatory, and antiatherogenic properties. Evidence is also accumulating that ADN …
Adiponectin receptor signalling in the brain
J Thundyil, D Pavlovski, CG Sobey… - British journal of …, 2012 - Wiley Online Library
Adiponectin is an important adipocyte‐derived hormone that regulates metabolism of lipids
and glucose, and its receptors (AdipoR1, AdipoR2, T‐cadherin) appear to exert actions in …
and glucose, and its receptors (AdipoR1, AdipoR2, T‐cadherin) appear to exert actions in …
Obesity and dementia: adipokines interact with the brain
IAC Arnoldussen, AJ Kiliaan, DR Gustafson - European …, 2014 - Elsevier
Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for
multiple conditions and contributes to multi-morbidities, resulting in increased health costs …
multiple conditions and contributes to multi-morbidities, resulting in increased health costs …
Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity
Beta-amyloid (Aβ) neurotoxicity is important in Alzheimer's disease (AD) pathogenesis. Aβ
neurotoxicity causes oxidative stress, inflammation and mitochondrial damage resulting in …
neurotoxicity causes oxidative stress, inflammation and mitochondrial damage resulting in …
Neuroactive peptides as putative mediators of antiepileptic ketogenic diets
C Giordano, M Marchiò, E Timofeeva… - Frontiers in neurology, 2014 - frontiersin.org
Various ketogenic diet (KD) therapies, including classic KD, medium chain triglyceride
administration, low glycemic index treatment, and a modified Atkins diet, have been …
administration, low glycemic index treatment, and a modified Atkins diet, have been …
Physiological role of adiponectin in different tissues: a review
S Esmaili, M Hemmati, M Karamian - Archives of physiology and …, 2020 - Taylor & Francis
Adiponectin is the most important adipokine secreted by the adipose tissue. It carries out an
important role in setting up the metabolism and improving the function of various organs …
important role in setting up the metabolism and improving the function of various organs …
Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity
Caloric restriction (CR) protects against many cerebral pathological conditions that are
associated with excitotoxic damage and calcium overload, although the mechanisms are still …
associated with excitotoxic damage and calcium overload, although the mechanisms are still …
Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines
L Letra, I Santana, R Seiça - Metabolic brain disease, 2014 - Springer
Alzheimer's disease is the leading cause of dementia and the most prevalent
neurodegenerative disease. It is an aging-related multi-factorial disorder and growing …
neurodegenerative disease. It is an aging-related multi-factorial disorder and growing …