The future of early cancer detection

RC Fitzgerald, AC Antoniou, L Fruk, N Rosenfeld - Nature medicine, 2022 - nature.com
A proactive approach to detecting cancer at an early stage can make treatments more
effective, with fewer side effects and improved long-term survival. However, as detection …

New opportunities and old challenges in the clinical translation of nanotheranostics

PJ Gawne, M Ferreira, M Papaluca, J Grimm… - Nature reviews …, 2023 - nature.com
Nanoparticle-based systems imbued with both diagnostic and therapeutic functions, known
as nanotheranostics, have enabled remarkable progress in guiding focal therapy, inducing …

Metallodrugs in cancer nanomedicine

Q Peña, A Wang, O Zaremba, Y Shi… - Chemical society …, 2022 - pubs.rsc.org
Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

Nanoparticles in the clinic: An update

AC Anselmo, S Mitragotri - Bioengineering & translational …, 2019 - Wiley Online Library
Nanoparticle drug delivery systems have been used in the clinic since the early 1990's.
Since that time, the field of nanomedicine has evolved alongside growing technological …

Enhancing cancer immunotherapy with nanomedicine

DJ Irvine, EL Dane - Nature Reviews Immunology, 2020 - nature.com
Therapeutic targeting of the immune system in cancer is now a clinical reality and marked
successes have been achieved, most notably through the use of checkpoint blockade …

Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Nanomedicine-based commercial formulations: Current developments and future prospects

RK Thapa, JO Kim - Journal of Pharmaceutical Investigation, 2023 - Springer
Background In recent decades, there has been a considerable increase in the number of
nanomedicine-based formulations, and their advantages, including controlled/targeted drug …

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

JD Martin, H Cabral, T Stylianopoulos… - Nature reviews Clinical …, 2020 - nature.com
Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

[HTML][HTML] Delivering the power of nanomedicine to patients today

M Germain, F Caputo, S Metcalfe, G Tosi… - Journal of Controlled …, 2020 - Elsevier
The situation of the COVID-19 pandemic reminds us that we permanently need high-value
flexible solutions to urgent clinical needs including simplified diagnostic technologies …

Nanoparticle‐mediated radiotherapy remodels the tumor microenvironment to enhance antitumor efficacy

W Zhen, RR Weichselbaum, W Lin - Advanced Materials, 2023 - Wiley Online Library
Radiotherapy (RT) uses ionizing radiation to eradicate localized tumors and, in rare cases,
control tumors outside of the irradiated fields via stimulating an antitumor immune response …