Implant-related infection may be catastrophic and result in poor functional outcome, chronic
osteomyelitis, implant failure or even sepsis and death. Based on a transglutaminase …

To prevent infections local delivery of antibiotics is a useful tool. Especially in bone fractures,
vancomycin impregnated bone cements are often used allowing high concentrations of …

Antimicrobial drugs of several classes play an important role in the treatment of bone and
joint infections. In addition to fighting pathogenic microorganisms, the effects of drugs on …

Background: Prophylactic vancomycin treatment decreases the prevalence of surgical site
and deep infections by> 70% in diabetic patients undergoing reconstructive foot and ankle …

Treatment of infected nonunions and severe bone infections is a huge challenge in modern
orthopedics. Their treatment routinely includes the use of anti-infective agents. Although …

Bioceramic porous microspheres are promising substances for dental and orthopedic bone
void filling, tissue engineering and drug delivery applications. In this research, the structure …

Aims Chronic osteomyelitis, including implant-related prosthetic joint infection, is extremely
difficult to cure. We develop vancomycin containing release systems from poly (d, l …

Objective This study tests the elution capabilities of a magnesium phosphate cement (MPC).
Study objectives were to quantify the passive release of magnesium ions from MPC and to …

Mesenchymal stem cells (MSCs) are extremely valuable in veterinary and human medicine
due to their potential application in regenerative medicine. The purpose of this study was to …

Background Local antibiotic application has been widely used in orthopedic surgery. The
dose-related toxicity of antibiotics towards periosteal tissues and resulting effects on …